Ultra-miniaturised spatial frequency domain imaging for improved early detection of gastrointestinal cancers
Ultra-miniaturised spatial frequency domain imaging for improved early detection of gastrointestinal cancers
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DOI：
10.1117/12.2648766
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发表时间：
2023-03
期刊：
影响因子：
--
通讯作者：
J. Crowley;G. Gordon
中科院分区：
文献类型：
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作者：
J. Crowley;G. Gordon
胃肠道癌症的五年生存率很低，这表明临床上迫切需要提高他们的早期发现。目前用于早期检测的成像方法昂贵，而且依赖于白光成像，而白光成像缺乏足够的对比度来发现广泛的潜在肿瘤。吸收系数和散射系数的改变可能与癌前病变有关，如Barrett‘s食道和食道浸润性鳞癌。空间频域成像(SFDI)是一种低成本的成像技术，利用结构照明可以获得定量的吸收图和减少的散射系数。我们开发了一种临床上可平移的超小型化SFDI系统，该系统使用光纤(直径0.125 mm)投射结构照明，并使用微型相机(直径1 mm)捕捉被测样品的图案响应。因此，整个封装可以制成1.1毫米直径，据我们所知，这是迄今为止实现的最小的完整SFDI探头。我们已经展示了利用我们的系统恢复吸收和减少散射图，以组织模拟具有生物相关吸收和散射特性的石油模体中的共聚聚合物。这项技术代表着朝着侵入性更小、成本效益更高的设备迈出了第一步，这种设备可以产生接近实时的吸收和减少的散射图，用于改进胃肠道疾病的体内检测。
The low five year-survival rates for gastrointestinal cancers evidences a strong clinical need to improve their early detection. Current imaging methods for early detection are expensive and rely on white light imaging which lacks sufficient contrast to spot a wide range of potential tumours. Changes in absorption and reduced scattering coefficients can be linked to pre-cancerous abnormalities, such as Barrett’s Oesophagus, and invasive squamous cell carcinoma, in the oesophagus. Spatial Frequency Domain Imaging (SFDI) is a low-cost imaging technique from which quantitative maps of absorption and reduced scattering coefficients may be obtained using structured illumination. We have developed a clinically translatable, ultra-miniaturised SFDI system using optical fibers (0.125 mm diameter) to project structured illumination and a miniature camera (< 1 mm diameter) to capture the pattern response for a sample under test. The total package could therefore be made < 1.1mm diameter, representing, to the best of our knowledge, the smallest full SFDI probe achieved to date. We have demonstrated recovery of absorption and reduced scattering maps with our system for tissue mimicking co-polymer in oil phantoms of biologically relevant absorption and scattering properties. This technology represents a first step towards a less-invasive, cost-effective device which produces close to real-time absorption and reduced scattering maps for improved in vivo disease detection of the gastrointestinal tract.