Anticryptosporidial activity of lasalocid and other ionophorous antibiotics in immunosuppressed rats.
Anticryptosporidial activity of lasalocid and other ionophorous antibiotics in immunosuppressed rats.
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拉沙里菌素和其他离子载体抗生素对免疫抑制大鼠的抗隐孢子虫活性。
DOI：
10.1093/infdis/168.6.1566
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Rehg,JE
中科院分区：
文献类型：
--
作者：
Rehg,JE
用地塞米松免疫抑制大鼠感染微小隐孢子虫，评价了三种离子型抗生素的抗隐孢子虫活性.当给药时，拉沙洛西以剂量依赖性方式预防感染，而莫能菌素和盐霉素无效。在治疗上，拉沙洛西消除了已建立的肠道明显感染，尽管在停止拉沙洛西治疗后，胆总管感染持续存在，肠道感染复发。这些发现表明拉沙洛昔是一种潜在的有效的抗隐孢子虫药物，但在免疫功能低下的宿主中长期连续给药可能是必要的。
The anticryptosporidial activities of three ionophorous antibiotics wereassessed in dexamethasone- immunosuppressed rats infected withCryptosporidium parvum. When administered prophylactically, lasalocid prevented infection in a dose-dependent manner, whereas monensin and salinomycin were ineffective. Therapeutically, lasalocid eliminated established overt infections of the intestine, although infection persisted in the common bile duct and intestinal infection recurred after lasalocid treatment was stopped. These findings suggest that lasalocid is a potentially useful anticryptosporidial agent but that long-term continuous administration may benecessary in the immunocompromised host.