THE NATURAL-HISTORY OF ABDOMINAL AORTIC-ANEURYSMS
THE NATURAL-HISTORY OF ABDOMINAL AORTIC-ANEURYSMS
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DOI：
10.1016/0002-9610(91)90266-g
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发表时间：
1991-11-01
影响因子：
3
通讯作者：
BARBER, GG
中科院分区：
文献类型：
--
作者：
GUIRGUIS, EM;BARBER, GG
本研究探讨腹主动脉瘤的扩张率和破裂风险与其大小的关系。为了评估这些变量，我们对300例连续患者进行了一项前瞻性研究，这些患者在6年内出现腹主动脉瘤（AAA），最初接受非手术治疗。患者的平均年龄为70.4岁，211例（70%）为男性。平均初始动脉瘤直径为4.1 cm。在208例接受一次以上超声或计算机断层扫描（CT）扫描的患者中，动脉瘤直径每年平均增加0.3 cm。动脉瘤直径小于4.0 em和4.0 - 4.9 em患者的6年累积破裂发生率分别为1%和2%（p > 0.05）。相比之下，动脉瘤直径大于5.0 cm的患者的6年累积破裂发生率为20（p < 0.004）。我们得出结论：（1）腹主动脉瘤以每年0.3 cm的中位速率扩张，以及（2）小于5.0 cm的腹主动脉瘤破裂的风险显著低于直径为5.0 cm或更大的动脉瘤破裂的风险。
This study examines the rate of expansion of abdominal aortic aneurysms and the risk of rupture in relation to their size. To assess these variables, we conducted a prospective study of 300 consecutive patients who presented over a 6-year interval with abdominal aortic aneurysms (AAA) that were initially managed nonoperatively. The mean age of the patients was 70.4 years, and 211 (70%) were men. The mean initial aneurysm diameter was 4.1 cm.Among the 208 patients who underwent more than one ultrasound or computed tomographic (CT) scan, the diameter of the aneurysm increased by a median of 0.3 cm per year. The 6-year cumulative incidence of rupture was 1% and 2% among patients with aneurysms less than 4.0 em and 4.0 to 4.9 em in diameter, respectively (p > 0.05). In comparison, the 6-year cumulative incidence of rupture was 20% among patients with aneurysms greater than 5.0 cm in diameter (p < 0.004).We conclude that (1) abdominal aortic aneurysms expand at a median rate of 0.3 cm per year, and (2) the risk of rupture of abdominal aortic aneurysms less than 5.0 cm is substantially lower than the risk of rupture of aneurysms 5.0 cm or more in diameter.