Perceived food intolerance in subjects with irritable bowel syndrome - etiology, prevalence and consequences
Perceived food intolerance in subjects with irritable bowel syndrome - etiology, prevalence and consequences
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DOI：
10.1038/sj.ejcn.1602367
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发表时间：
2006-05-01
影响因子：
4.7
通讯作者：
Farup, PG
中科院分区：
文献类型：
--
作者：
Monsbakken, KW;Vandvik, PO;Farup, PG
目的：本研究估计肠易激综合征（IBS）患者感知食物不耐受的患病率及其后果，评估常见食物不耐受测试的效用，研究感知食物不耐受与其他疾病之间的关系，并讨论病因。设计：横断面研究。背景：全国健康调查。研究对象：选取挪威Oppland县的人群（n=11078）进行健康筛查，其中包括肠易激综合征患者。干预措施：记录了食物不耐受、肌肉骨骼疼痛、情绪障碍和腹部不适的病史，并进行了食物过敏和吸收不良的测试。一位营养师评估了受试者的饮食习惯。结果：在4622名填写了充分问卷的受试者中，84人被纳入研究，59人（70%）有与食物摄入有关的症状，62%的人限制或排除饮食中的食物，12%的人饮食不足。与症状相关的食物的平均数量以及限制或排除在饮食之外的食物的数量分别为4.8和2.5。食物过敏、吸收不良和食物不耐受试验之间没有关联。感知到的食物不耐受与肌肉骨骼疼痛和情绪障碍无关。结论：感知食物不耐受是肠易激综合征人群中具有显著营养后果的常见问题。目前抗体测试和吸收不良测试的无用性以及缺乏与精神合并症的相关性使得病因不明。赞助：挪威innlanddet医院卫生局。
Objectives: This study estimates the prevalence of perceived food intolerance and its consequences in subjects with irritable bowel syndrome (IBS), evaluates the utility of common tests for food intolerance, studies the relation between perceived food intolerance and other disorders, and discusses the etiology.Design: Cross-sectional study.Setting: National health survey.Subjects: A selection of the population (n=11078) in Oppland county, Norway, was invited to a health screening, and a sample of subjects with IBS were included in the study.Interventions: A medical history of food intolerance, musculoskeletal pain, mood disorders and abdominal complaints was taken, and tests were performed for food allergy and malabsorption. A dietician evaluated the dietary habits of the subjects.Results: Out of 4622 subjects with adequately filled-in questionnaires, 84 were included in the study, 59 (70%) had symptoms related to intake of food, 62% limited or excluded food items from the diet and 12% had an inadequate diet. The mean numbers of food items related to symptoms and the number of foods limited or excluded from the diet were 4.8 and 2.5, respectively. There were no associations between the tests for food allergy and malabsorption and perceived food intolerance. Perceived food intolerance was unrelated to musculoskeletal pain and mood disorders.Conclusions: Perceived food intolerance is a common problem with significant nutritional consequences in a population with IBS. The uselessness of current antibody tests and tests for malabsorption and the lack of correlation to psychiatric co-morbidity make the etiology obscure.Sponsorship: Innlandet Hospital Health Authority, Norway.