Left hemisphere fractional anisotropy increase in noise-induced tinnitus: A diffusion tensor imaging (DTI) study of white matter tracts in the brain
Left hemisphere fractional anisotropy increase in noise-induced tinnitus: A diffusion tensor imaging (DTI) study of white matter tracts in the brain
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DOI：
10.1016/j.heares.2013.10.005
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发表时间：
2014-03-01
期刊：
影响因子：
2.8
通讯作者：
Cacace, Anthony T.
中科院分区：
文献类型：
--
作者：
Benson, Randall R.;Gattu, Ramtilak;Cacace, Anthony T.
扩散张量成像（DTI）是一种现代神经成像方式，用于研究大脑中白色物质束的连接模式和微观结构。在耳鸣的研究中使用DTI是一种相对未开发的方法，没有专门针对噪声暴露引起的耳鸣的研究。在这项调查中，参与者是两组在病因、年龄和周围听力损失程度上相匹配的成年人，但耳鸣的存在或不存在（+/-）不同。假设基于外周听力损失的匹配个体允许区分由于听力损失引起的白色物质微观结构的变化与由于慢性耳鸣的影响引起的变化。白色物质束的改变，使用分数各向异性（FA）度量，测量水的定向扩散，使用基于束的空间统计（TBSS）与在体概率纤维束成像提供的额外细节进行量化。我们的研究结果表明，10体素集群区分两组，其中包括9个较高的FA组耳鸣。在耳鸣组中，发现单个簇的FA降低。然而，9个具有较高FA的簇中有7个在左半球丘脑、额叶和顶叶白色物质中。这些病灶局限于丘脑前放射和下、上级纵束。FA增加的两个右侧簇位于额枕下束和上级纵束。耳鸣阳性组的FA仅在左顶叶的上级纵束中发现。(C)2013爱思唯尔有限公司版权所有。
Diffusion tensor imaging (DTI) is a contemporary neuroimaging modality used to study connectivity patterns and microstructure of white matter tracts in the brain. The use of DTI in the study of tinnitus is a relatively unexplored methodology with no studies focusing specifically on tinnitus induced by noise exposure. In this investigation, participants were two groups of adults matched for etiology, age, and degree of peripheral hearing loss, but differed by the presence or absence (+/-) of tinnitus. It is assumed that matching individuals on the basis of peripheral hearing loss, allows for differentiating changes in white matter microstructure due to hearing loss from changes due to the effects of chronic tinnitus. Alterations in white matter tracts, using the fractional anisotropy (FA) metric, which measures directional diffusion of water, were quantified using tract-based spatial statistics (TBSS) with additional details provided by in viva probabilistic tractography. Our results indicate that 10 voxel clusters differentiated the two groups, including 9 with higher FA in the group with tinnitus. A decrease in FA was found for a single cluster in the group with tinnitus. However, seven of the 9 clusters with higher FA were in left hemisphere thalamic, frontal, and parietal white matter. These foci were localized to the anterior thalamic radiations and the inferior and superior longitudinal fasciculi. The two right-sided clusters with increased FA were located in the inferior fronto-occipital fasciculus and superior longitudinal fasciculus. The only decrease in FA for the tinnitus-positive group was found in the superior longitudinal fasciculus of the left parietal lobe. (C) 2013 Elsevier B.V. All rights reserved.