The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study
The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study
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DOI：
10.1136/thoraxjnl-2015-208154
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发表时间：
2017-03-01
期刊：
影响因子：
10
通讯作者：
Dharmage, S. C.
中科院分区：
文献类型：
--
作者：
Campbell, B.;Raherison, C.;Dharmage, S. C.
有证据表明，在生命早期暴露于环境或微生物生物多样性可能会影响随后的肺功能和过敏性疾病的风险。目的探讨儿童生活环境和生物多样性指标对特应性的影响，方法和测量欧洲共同体呼吸健康调查II调查了10201名年龄在26- 28岁的参与者，来自14个国家的54岁，包括参与者5岁前的成长地点（农场、农村环境或市中心）。根据儿童时期接触猫、狗、日托、卧室共享和哥哥姐姐的情况，建立了一个“生物多样性评分”。与肺功能，支气管高反应性（BHR），过敏性，哮喘和鼻炎的关系进行了分析。主要结果与城市相比，那些早期生活在农场的人有较少的特应性过敏（调整OR 0.46，95%CI 0.37 - 0.58），特应性BHR（0.54（0.35 - 0.83）），特应性哮喘（0.47（0.28 - 0.81））和特应性鼻炎（0.43（0.32 - 0.57）），但非特应性结局。农村环境暴露的保护效果不太明显。在农场长大的女性FEV 1更高（校正差异110 mL（64 - 157）），与过敏和哮喘无关。在内城的环境中，更高的生物多样性得分与过敏性sensitisation.Conclusions这是第一个研究报告的有益影响，在农场长大成人FEV 1。我们的研究证实了早期农场生活对过敏，哮喘和鼻炎的有益影响，并发现了BHR的类似关联。在城市长大的人，较高的生物多样性得分预测过敏性较低，但比童年农场环境的程度要小。
Rationale Evidence has suggested that exposure to environmental or microbial biodiversity in early life may impact subsequent lung function and allergic disease risk.Objectives To investigate the influence of childhood living environment and biodiversity indicators on atopy, asthma and lung function in adulthood.Methods and measurements The European Community Respiratory Health Survey II investigated similar to 10 201 participants aged 26-54 years from 14 countries, including participants' place of upbringing (farm, rural environment or inner city) before age 5 years. A 'biodiversity score' was created based on childhood exposure to cats, dogs, day care, bedroom sharing and older siblings. Associations with lung function, bronchial hyper-responsiveness (BHR), allergic sensitisation, asthma and rhinitis were analysed.Main results As compared with a city upbringing, those with early-life farm exposure had less atopic sensitisation (adjusted OR 0.46, 95% CI 0.37 to 0.58), atopic BHR (0.54 (0.35 to 0.83)), atopic asthma (0.47 (0.28 to 0.81)) and atopic rhinitis (0.43 (0.32 to 0.57)), but not non-atopic outcomes. Less pronounced protective effects were observed for rural environment exposures. Women with a farm upbringing had higher FEV1 (adjusted difference 110 mL (64 to 157)), independent of sensitisation and asthma. In an inner city environment, a higher biodiversity score was related to less allergic sensitisation.Conclusions This is the first study to report beneficial effects of growing up on a farm on adult FEV1. Our study confirmed the beneficial effects of early farm life on sensitisation, asthma and rhinitis, and found a similar association for BHR. In persons with an urban upbringing, a higher biodiversity score predicted less allergic sensitisation, but to a lesser magnitude than a childhood farm environment.