Role of 64CuCl2 PET/CT in staging of prostate cancer
Role of 64CuCl2 PET/CT in staging of prostate cancer
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DOI：
10.1007/s12149-015-0968-4
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发表时间：
2015-07-01
影响因子：
2.6
通讯作者：
Mirzaei, Siroos
中科院分区：
文献类型：
--
作者：
Capasso, Enza;Durzu, Silvia;Mirzaei, Siroos
癌细胞中铜浓度升高的存在可能用于区分健康细胞和转化细胞。本研究旨在探讨（CuCl 2）-Cu-64 PET/CT在前列腺癌（PC）分期中的可能作用。3例患者在成像时接受肾上腺剥夺治疗（ADT）。其余4例患者未接受ADT、手术或外束放射治疗（EBRT）。在所有患者中，在平均339 MBq（CuCl 2）-Cu-64给药后10 min、1 h和3 h进行多达3次（CuCl 2）-Cu-64 PET/CT扫描（2例患者中额外扫描24 h），并分析疾病的存在。此外，还进行了剂量测定计算。所有患者都接受了多参数磁共振成像（mMRI）以确认疾病。由于没有尿液排泄示踪剂，因此可以很容易地描绘骨盆区域的病变。未接受ADT治疗的患者的原发性肿瘤中（CuCl 2）-Cu-64摄取高于接受比卡鲁胺治疗的患者。在2例MRI疑似淋巴结病（直径> 10 mm）的患者中，（CuCl 2）-Cu-64摄取无增强。另外2例患者的受累盆腔淋巴结有局灶性增强摄取，其中1例正常大小< 10 mm。本研究的初步结果显示，PC和受累区域淋巴结中（CuCl 2）-Cu-64的高摄取表明（CuCl 2）-Cu-64 PET/CT在前列腺癌患者的原发分期中具有很大的潜力。
The presence of an elevated copper concentration in cancer cells may be potentially used to differentiate healthy from transformed cells. In this study, we aimed to look at the possible role of (CuCl2)-Cu-64 PET/CT in staging of patients with prostate cancer (PC).Seven patients affected by histologically confirmed PC have been prospectively enrolled. Three patients underwent adrenal deprivation therapy (ADT) at time of imaging. The remaining four patients had no ADT, surgery, or external beam radiation therapy (EBRT). In all patients, up to three (CuCl2)-Cu-64 PET/CT scans 10 min, 1 h and 3 h (and an additional scan 24 h in 2 patients) after administration of mean 339 MBq (CuCl2)-Cu-64 were performed and analyzed for presence of disease. Additionally, dosimetric calculations were performed. All patients underwent a multiparametric magnetic resonance imaging (mMRI) for confirmation of disease.Lesions specifically in the pelvic area could be easily delineated, which was due to the absence of urinary excretion of the tracer. (CuCl2)-Cu-64 uptake was higher in primary tumors of patients without ADT than in patients under bicalutamide therapy. In two patients with suspected lymphadenopathy at MRI (> 10 mm diameter), there was no enhanced (CuCl2)-Cu-64 uptake. In other two patients, there was focal enhanced uptake in involved pelvic lymph nodes, one of which with a normal size of < 10 mm.The preliminary results of this study show a high uptake of (CuCl2)-Cu-64 in PC and involved regional lymph nodes indicating to a great potential of (CuCl2)-Cu-64 PET/CT for primary staging of patients with prostate cancer.