Pericardial Adipose Tissue Determined by Dual Source CT Is a Risk Factor for Coronary Atherosclerosis
Pericardial Adipose Tissue Determined by Dual Source CT Is a Risk Factor for Coronary Atherosclerosis
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DOI：
10.1161/atvbaha.108.180653
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发表时间：
2009-05-01
影响因子：
8.7
通讯作者：
Leber, Alexander W.
中科院分区：
文献类型：
--
作者：
Greif, Martin;Becker, Alexander;Leber, Alexander W.
目的：心包脂肪作为内脏脂肪储存库可能参与冠状动脉粥样硬化的发病机制。为了获得这一概念的证据，我们试图调查心包脂肪体积与危险因素、血清脂联素水平、炎症生物标志物以及冠状动脉粥样硬化的数量和形态的关系。方法和结果-使用双源CT血管成像同时评估心包脂肪体积和冠状动脉粥样硬化。斑块分为钙化斑块、混合斑块和非钙化斑块，以病变节段数作为定量评分。有动脉粥样硬化组的PAT体积(226cm3+/-92cm3)显著大于无动脉粥样硬化组(134cm3+/-56cm3；P>；0.001)。未发现BMI与冠状动脉粥样硬化之间存在关联。PAT体积300 cm(3)是冠状动脉粥样硬化的最强独立危险因素(优势比4.1；可信区间3.63至4.33)，与Framingham评分相比也明显更强。我们进一步证明，PAT容量的增加与低脂联素水平、低高密度脂蛋白水平、高肿瘤坏死因子-α水平和hsCRP.水平显著相关。结论：在本研究中，我们证明PAT容量的增加与冠状动脉粥样硬化、低脂联素血症和炎症有关，是动脉粥样硬化存在的最强危险因素，可能对风险分层和监测很重要。(动脉血栓血管生物)2009年；29：781-786。)
Objectives-Pericardial fat as a visceral fat depot may be involved in the pathogenesis of coronary atherosclerosis. To gain evidence for that concept we sought to investigate the relation of pericardial fat volumes to risk factors, serum adiponectin levels, inflammatory biomarkers, and the quantity and morphology of coronary atherosclerosis.Methods and Results-Using Dual source CT angiography pericardial fat volume and coronary atherosclerosis were assessed simultaneously. Plaques were classified as calcified, mixed, and noncalcified, and the number of affected segments served as quantitative score. Patients with atherosclerotic lesions had significant larger PAT volumes (226 cm(3) +/- 92 cm(3)) than patients without atherosclerosis (134 cm(3) +/- 56 cm(3); P > 0.001). No association was found between BMI and coronary atherosclerosis. PAT volumes > 300 cm(3) were the strongest independent risk factor for coronary atherosclerosis (odds ratio 4.1; CI 3.63 to 4.33) also significantly stronger compared to the Framingham score. We furthermore demonstrated that elevated PAT volumes are significantly associated with low adiponectin levels, low HDL levels, elevated TNF-alpha levels, and hsCRP.Conclusion-In the present study we demonstrated that elevated PAT volumes are associated with coronary atherosclerosis, hypoadiponectinemia, and inflammation and represent the strongest risk factor for the presence of atherosclerosis and may be important for risk stratification and monitoring. (Arterioscler Thromb Vasc Biol. 2009; 29: 781-786.)