Molecular imprinting for drug bioanalysis - A review on the application of imprinted polymers to solid-phase extraction and binding assay
Molecular imprinting for drug bioanalysis - A review on the application of imprinted polymers to solid-phase extraction and binding assay
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DOI：
10.1016/s0378-4347(99)00432-6
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发表时间：
2000-02-28
期刊：
影响因子：
--
通讯作者：
Andersson, LI
中科院分区：
文献类型：
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作者：
Andersson, LI
分子印迹聚合物已作为选择性吸附剂应用于多种分析技术，包括液相色谱、毛细管电泳和毛细管电色谱、固相萃取和“免疫分析”。这种类型的吸附剂的优点是有可能合成具有特定分析物预先确定的选择性的聚合物。这篇综述批判性地讨论了印迹聚合物在生物样品中药物和其他化合物分析中的应用，重点是它们作为高选择性固相萃取吸附剂用于样品预浓缩和免疫测定类型协议中的替代结合实体。(C) 2000 Elsevier Science B.V.版权所有
Molecularly imprinted polymers have been applied as selective sorbents in several analytical techniques, including liquid chromatography, capillary electrophoresis and capillary electrochromatography, solid-phase extraction, and 'immunoassay'. An advantage of this type of sorbent is the possibility to synthesize polymers with selectivity pre-determined for a particular analyte. This review critically discusses the use of imprinted polymers for analysis of drugs and other compounds in biological samples, with emphasis on their use as highly selective solid-phase extraction sorbents for sample preconcentration and alternative binding entities in immunoassay type protocols. (C) 2000 Elsevier Science B.V. All rights reserved.