Isolated mesenteric arteries from pregnant rats show enhanced flow-mediated relaxation but normal myogenic tone
Isolated mesenteric arteries from pregnant rats show enhanced flow-mediated relaxation but normal myogenic tone
复制标题
怀孕大鼠的离体肠系膜动脉显示血流介导的松弛增强，但肌源性张力正常
DOI：
10.1113/jphysiol.1996.sp021614
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发表时间：
1996-09-01
影响因子：
5.5
通讯作者：
Poston, L
中科院分区：
文献类型：
--
作者：
Cockell, AP;Poston, L
1.血管适应妊娠的机制仍有待充分阐明。本研究比较了晚期妊娠和非妊娠Wistar大鼠第五代肠系膜动脉的血流诱导性扩张和肌源性反应.肌源性张力，评估为内径（i.d.）在存在和不存在外部钙的情况下，在六个跨壁压阶（40-90 mmHg）中的每一个，妊娠和非妊娠动物的动脉中没有差异（90 mmHg;妊娠动物，20.5 +/-3.2% i.d.变化，n = 13;非妊娠动物，i.d.变化14.4 ± 4.4%，n = 13; n.s.）。3.与未妊娠动物相比，妊娠动物的动脉血流诱导扩张显著增加（妊娠，i.d增加11.2 ± 3.7%，n = 12;未妊娠，1.2 ± 1.0%，n = 8; P
1. The mechanisms of vascular adaptation to pregnancy remain to be fully elucidated. In this study we have compared flow-induced dilatation and myogenic responses in fifth generation mesenteric arteries from late pregnant and non-pregnant Wistar rats.2. Myogenic tone, assessed as the difference between internal diameter (i.d.) in the presence and absence of external calcium, at each of six transmural pressure steps (40-90 mmHg) was no different in arteries from pregnant and non-pregnant animals (90 mmHg; pregnant animals, 20.5 +/- 3.2% change in i.d., n = 13; non-pregnant animals, 14.4 +/- 4.4% change in i.d., n = 13; n.s.).3. Flow-induced dilatation was significantly increased in arteries from pregnant-animals when compared with that in non-pregnant animals (pregnant, 11.2 +/- 3.7% increase in i.d n = 12; non-pregnant, 1.2 +/- 1.0%, n = 8; P