Hypervalent-Iodine(III)-Mediated Tandem Oxidative Dearomatization/Aziridination of Phenolic Amines: Synthesis of Functionalized Unactivated Aziridines
Hypervalent-Iodine(III)-Mediated Tandem Oxidative Dearomatization/Aziridination of Phenolic Amines: Synthesis of Functionalized Unactivated Aziridines
复制标题
高价碘 (III) 介导的酚胺串联氧化脱芳构化/氮丙啶化：功能化未活化氮丙啶的合成
DOI：
10.1002/chem.202100762
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Fan Chun-An
中科院分区：
文献类型：
--
作者：
Cao Ye-Xing;Silalai Patamawadee;Liu Chun-Fang;Yu Ke-Yin;Bao Xu;Zhao Xian-He;Saeeng Rungnapha;Fan Chun-An
描述了一种新的高价碘（III）介导的串联反应，涉及酚胺的氧化脱芳构化和原位氮丙啶化，为组装结构有趣且合成有用的氮丙啶提供了温和有效的方法。重要的是，这种前所未有的串联反应产生的密集功能化的氮丙啶提供了一个平台，可以通过氮丙啶选择性开环引发的转化，快速获得结构多样的氮杂杂环。
A new hypervalent-iodine(III)-mediated tandem reaction involving oxidative dearomatization and in situ aziridination of phenolic amines is described, providing a mild and effective method for the assembly of structurally interesting and synthetically useful aziridines. Importantly, the densely functionalized aziridines resulting from this unprecedented tandem reaction offer a platform for expeditious access to architecturally diverse aza-heterocycles through transformations initiated by selective ringopening of aziridines.