Radiotherapy for lymph node metastases in patients with hepatocellular carcinoma: Retrospective study
Radiotherapy for lymph node metastases in patients with hepatocellular carcinoma: Retrospective study
复制标题
DOI：
10.1111/j.1440-1746.2006.04450.x
复制
发表时间：
2007-04-01
影响因子：
4.1
通讯作者：
Ohtomo, Kuni
中科院分区：
文献类型：
--
作者：
Yamashita, Hideomi;Nakagawa, Keiichi;Ohtomo, Kuni
目的：本研究旨在评价体外放射治疗对肝细胞癌（HCC）淋巴结转移的效果。方法：对28例细胞病理学证实的HCC患者进行了为期5年的放射治疗，其中01例继续治疗。所有患者均接受总剂量为 46 至 60 Gy 的照射，每日 2.0Gy，每周 5 次。 结果：在治疗的转移病灶中，分别有 18 名（64%）和 5 名（18%）患者获得部分缓解和完全缓解。以非姑息性、接近治愈为目的而接受外照射放射治疗 (EBRT) 的患者 (n = 21)，1 年和 2 年总生存率和中位生存时间分别为 53% 和 33%，生存时间为 13 个月。 结论：虽然 HCC 淋巴结转移对 EBRT 敏感，但 EBRT 的目的应仅限于姑息治疗。出于姑息治疗的目的，对这些患者进行 25 次 50 Gy 的治疗是有用的。
Aim: This study was conducted to evaluate the effect of external radiation therapy on lymph node metastases from hepatocellular carcinoma (HCC).Methods: A total 28 patients with cytopathologically proven HCC were subjected to radiation therapy over a 5-year period, and treatment was continued in 01 cases. All patients underwent irradiation with a total dose ranging between 46 and 60 Gy in daily 2.0Gy fractions, five times a week.Results: Among the metastatic lesions treated, 18 (64%) and five (18%) patients achieved partial responses and complete responses, respectively. The 1- and 2-year overall survival rates and the median survival time were 53% and 33%, respectively, and 13 months in patients given external beam radiation therapy (EBRT) for a non-palliative, near-cure intent (n = 21).Conclusions: Although lymph node metastasis from HCC is sensitive to EBRT, the intent of EBRT should be limited to palliation. For palliative purposes, it is useful in treatment with 50 Gy in 25 fractions for these patients.