HYPOTHALAMIC PARAVENTRICULAR NUCLEUS LESIONS PRODUCE OVEREATING AND OBESITY IN THE RAT
HYPOTHALAMIC PARAVENTRICULAR NUCLEUS LESIONS PRODUCE OVEREATING AND OBESITY IN THE RAT
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DOI：
10.1016/0031-9384(81)90366-8
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发表时间：
1981-01-01
影响因子：
2.9
通讯作者：
CHANG, K
中科院分区：
文献类型：
--
作者：
LEIBOWITZ, SF;HAMMER, NJ;CHANG, K
研究了PVN（下丘脑室旁核）内部和周围的电解损伤对大鼠食物摄入、水摄入和每日体重增加的影响。基本上局限于PVN的小病变会导致雌性和雄性大鼠吃实验室颗粒饲料或高脂肪糊状食物时暴饮暴食并增加体重。对于损害 PVN 尾部的病变，这种效应似乎最强。 PVN 背侧、腹侧或吻侧组织的破坏对食物摄入和体重没有影响或具有抑制作用。除 1 个例外外，延伸到细胞核边界之外的较大病变不会比仅限于 fPVN 的病变产生更大的反应。例外的是非常大的病变，它同时损害PVN和腹内侧下丘脑区域（在腹内侧核附近），并且在引起食欲亢进和肥胖方面比PVN损伤更有效。
The impact of electrolytic lesions within and around the PVN [hypothalamic paraventricular nucleus] on food intake, water intake and daily body weight gain in rats was investigated. Small lesions essentially restricted to the PVN produce overeating and increased body weight in both female and male rats maintained on either lab chow pellets or high fat mash. This effect appears to be strongest with lesions which damage the caudal aspect of the PVN. Destruction of tissue dorsal, ventral or rostral to the PVN has no effect, or a suppressive effect, on food intake and body weight. With 1 exception, larger lesions, which extend beyond the borders of the nucleus, produce no greater response than lesions restricted to the fPVN. The exception is a very large lesion which simultaneously damages the PVN and the ventromedial hypothalamic region (in the vicinity of the ventromedial nucleus) and which is somewhat more effective than PVN lesions in causing hyperphagia and obesity.