Egg white hydrolysate from simulated gastrointestinal digestion alleviates the inflammation and improves the nutritional status in TNBS-induced Crohn’s disease rats
Egg white hydrolysate from simulated gastrointestinal digestion alleviates the inflammation and improves the nutritional status in TNBS-induced Crohn’s disease rats
复制标题
模拟胃肠道消化的蛋清水解产物可减轻 TNBS 诱导的克罗恩病大鼠的炎症并改善营养状况
DOI：
10.1016/j.jff.2022.105288
复制
发表时间：
2022-11
影响因子：
5.6
通讯作者：
Long Ding
中科院分区：
文献类型：
--
作者：
Tianliang Wu;Juanrui Li;Wei Wang;Chenxi Xu;Liying Wang;Long Ding
·EWH可减少Cd大鼠体重下降和增加摄食量。·EWH可改善Cd大鼠的疾病活动性和结肠损伤。·EWH可降低CD大鼠结肠炎症水平。·EWH可增加CD大鼠结肠紧密连接蛋白的表达。·EWH可改善Cd大鼠的血浆营养状况。本文旨在探讨蛋清水解物(EWH)对克罗恩病的改善作用。雄性SD大鼠于第0天经直肠注射三硝基苯磺酸(TNBS)100 mg/kg复制CD模型，然后分别灌胃生理盐水(模型组，n=8)或EWH(1g/kg，EWH组，n=8)，连续4周。结果显示，与模型组比较，EWH组大鼠摄食量增加，体重下降，结肠组织病理损害减轻(P<；0.05)。EWH组的促炎细胞因子IL-1β、IL-6、IL-12、IL-17A、IL-23、肿瘤坏死因子-α降低，抗炎细胞因子IL-10升高(P<0.05)。此外，EWH还能提高结肠紧密连接蛋白的表达和血清总蛋白、白蛋白、前白蛋白、血红蛋白、转铁蛋白和淋巴细胞计数的水平(P<；0.05)。这意味着EWH作为功能性食品的一种成分在预防和治疗CD方面具有潜力。
• EWH reduced the body weight loss and increased food intake of CD rats. • EWH ameliorated the disease activity and colon damage of CD rats. • EWH reduced the level of inflammation in the colon of CD rats. • EWH increased the expression of tight junction proteins of the colon of CD rats. • EWH improved the nutritional status in the plasma of CD rats. This paper aimed to investigate the amelioration of egg white hydrolysate (EWH) in Crohn’s disease. Male Sprague-Dawley rats were rectally administrated trinitrobenzene sulfonic acid (TNBS) (100 mg/kg) at day 0 to induce CD and then intragastrically administrated saline (model group, n = 8) or EWH (1 g/kg) (EWH group, n = 8) for four weeks. Results showed that the EWH group had higher food intake, lower body weight loss, and colonic histopathological damage compared with the model group ( P < 0.05). In addition, the pro-inflammatory interleukin (IL)-1β, IL-6, IL-12, IL-17A, IL-23, and tumor necrosis factor-α were decreased but the anti-inflammatory IL-10 was increased in the EWH group ( P < 0.05). Moreover, EWH improved the expressions of tight junction proteins in the colon and the levels of total protein, albumin, prealbumin, hemoglobin, transferrin, and lymphocyte count in the serum ( P < 0.05). It implies the potential of EWH as an ingredient of functional foods in the prevention and management of CD.
登录
查看更多内容
影响因子：
9
作者：
Witkowski M;Witkowski M;Gagliani N;Huber S
通讯作者：
Huber S
影响因子：
5.6
作者：
Dai, Chen;Dai, Lin;Lu, Ya-Ping
通讯作者：
Lu, Ya-Ping
影响因子：
5.6
作者：
Hou, Yu-Chen;Liu, Jun-Jen;Yeh, Sung-Ling
通讯作者：
Yeh, Sung-Ling
影响因子：
29.4
作者：
B. Zingarelli;C. Szabó;A. Salzman
通讯作者：
B. Zingarelli;C. Szabó;A. Salzman
纯化水果菠萝蛋白酶抑制上皮 TNF-α 受体可改善结肠炎中的肠道炎症和屏障功能障碍
影响因子：
7.3
作者：
Zhou Z;Wang L;Feng P;Yin L;Wang C;Zhi S;Dong J;Wang J;Lin Y;Chen D;Xiong Y;Peng J
通讯作者：
Peng J