Emerging immunomodulatory strategies for cell therapeutics.
Emerging immunomodulatory strategies for cell therapeutics.
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DOI：
10.1016/j.tibtech.2022.11.008
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发表时间：
2022-12
影响因子：
17.3
通讯作者：
C. Y. Chua;A. Jiang;Tatiane Eufrásio-da-Silva;A. Dolatshahi-Pirouz;R. Langer;G. Orive;A. Grattoni
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文献类型：
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作者：
C. Y. Chua;A. Jiang;Tatiane Eufrásio-da-Silva;A. Dolatshahi-Pirouz;R. Langer;G. Orive;A. Grattoni
细胞疗法正准备通过修复功能失调的组织和以传统制药学无法实现的动态方式治疗各种疾病来改变医学领域。细胞疗法跨越包括癌症、再生医学和免疫紊乱在内的各种治疗领域，包括来自各种来源的干细胞或非干细胞。尽管许多临床批准或试验正在进行中，但宿主免疫反应是细胞疗法广泛采用和成功的关键障碍。在这里，我们回顾了当前免疫调节策略的研究和临床进展，以减轻免疫排斥反应或促进对细胞疗法的免疫耐受。我们讨论了这些免疫调节干预的潜力，以加速翻译或最大限度地提高临床成功的细胞疗法的治疗结果的前景。
Cellular therapies are poised to transform the field of medicine by restoring dysfunctional tissues and treating various diseases in a dynamic manner not achievable by conventional pharmaceutics. Spanning various therapeutic areas inclusive of cancer, regenerative medicine, and immune disorders, cellular therapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune response presents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immune tolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.