Organisational justice and markers of inflammation: the Whitehall II study
Organisational justice and markers of inflammation: the Whitehall II study
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DOI：
10.1136/oem.2008.044917
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发表时间：
2010-02-01
影响因子：
4.9
通讯作者：
Kivimaki, Mika
中科院分区：
文献类型：
--
作者：
Elovainio, Marko;Ferrie, Jane E.;Kivimaki, Mika
低组织公正性已被证明与各种健康问题的风险增加，但潜在的机制仍不清楚。我们测试是否组织的不公正有助于慢性炎症的人口中的中年男子和women.Methods这一前瞻性队列研究使用的数据从3205名男子和1204名妇女年龄在35-55岁进入白厅II研究（第1阶段，1985-1988年）。在第一阶段和第二阶段评估了组织正义感（1989-1990）和循环炎症标志物C-反应蛋白（CRP）和白细胞介素（IL）-6在3期（1991-1993年）和第7阶段结果在男子中，低组织公正性与两次随访（3期和7期）时CRP水平升高和第二次随访（7期）时IL-6升高相关。长期（第7阶段）关联在很大程度上独立于协变量，如年龄，就业等级，体重指数和抑郁症状。在女性中，组织公正和CRP或IL-6之间没有发现任何关系。结论本研究表明，组织不公正与男性炎症标志物的长期水平增加。
Objectives Low organisational justice has been shown to be associated with increased risk of various health problems, but the underlying mechanisms remain unclear. We tested whether organisational injustice contributes to chronic inflammation in a population of middle-aged men and women.Methods This prospective cohort study uses data from 3205 men and 1204 women aged 35-55 years at entry into the Whitehall II study (phase 1, 1985-1988). Organisational justice perceptions were assessed at phase 1 and phase 2 (1989-1990) and circulating inflammatory markers C-reactive protein (CRP) and interleukin (IL)-6 at phase 3 (1991-1993) and phase 7 (2003-2004).Results In men, low organisational justice was associated with increased CRP levels at both follow-ups (phase 3 and 7) and increased IL-6 at the second follow-up (phase 7). The long term (phase 7) associations were largely independent of covariates, such as age, employment grade, body mass index and depressive symptoms. In women, no relationship was found between organisational justice and CRP or IL-6.Conclusions This study suggests that organisational injustice is associated with increased long-term levels of inflammatory markers among men.