Relation of plasma prolactin to clinical response in schizophrenic patients.
Relation of plasma prolactin to clinical response in schizophrenic patients.
复制标题
血浆催乳素与精神分裂症患者临床反应的关系。
DOI：
10.1001/archpsyc.1978.01770340072008
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发表时间：
1978
影响因子：
--
通讯作者：
F. Halpern
中科院分区：
文献类型：
--
作者：
P. Gruen;E. Sachar;N. Altman;G. Langer;M. Tabrizi;F. Halpern
有人认为，如果多巴胺拮抗作用是精神抑制剂抗精神分裂症作用的必要条件，那么催乳素反应作为多巴胺阻断的指标，将与临床反应相关。对15例精神分裂症患者在抗精神病药物治疗前、大剂量布他拉嗪或洛沙坦治疗3周和6周后的晨起催乳素和临床泌乳学进行了测定。催乳素水平在未服药的住院期间短暂升高，可能反映了正常的应激反应。在抗精神病药物治疗期间，所有患者的催乳素均升高。然而，催乳素的变化幅度和临床反应之间没有相关性，这可能是因为催乳素反应在相对低剂量的精神抑制剂时达到最大值。
It has been suggested that, if dopamine antagonism is a necessary condition for the antischizophrenic action of neuroleptics, the prolactin response, as an index of dopamine blockade, would correlate with clinical response. Morning prolactin and clinical symptomatology were measured in 15 schizophrenic patients before neuroleptic therapy, and after three and six weeks of high-dose butaperazine or loxapine treatment. Prolactin levels were transiently elevated during the unmedicated admission period, probably reflecting a normal stress response. Prolactin increased in all patients during neuroleptic therapy. There was, however, no correlation between magnitude of prolactin changes and clinical response, probably because the prolactin response achieved a maximum at relatively low doses of neuroleptics.