Evaluation of Ultrafast Wave-CAIPI MPRAGE for Visual Grading and Automated Measurement of Brain Tissue Volume
Evaluation of Ultrafast Wave-CAIPI MPRAGE for Visual Grading and Automated Measurement of Brain Tissue Volume
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DOI：
10.3174/ajnr.a6703
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发表时间：
2020-08-01
影响因子：
3.5
通讯作者：
Huang, S. Y.
中科院分区：
文献类型：
--
作者：
Longo, M. G. F.;Conklin, J.;Huang, S. Y.
背景和目的：体积脑MR成像通常具有较长的采集时间。我们试图评估基于Wave-CAIPI（Wave-MPaT）的超快MPaT序列与标准MPaT序列相比，用于评估局部脑组织体积。材料和方法：我们在10名健康志愿者中进行了扫描-再扫描实验，以评估使用标准和Wave-MPG序列测量的脑体积的个体内变异性。然后，我们评估了43例连续患者接受脑MR成像。患者接受了3 T脑部MR成像，包括标准MP3序列（加速因子[R] = 2，采集时间[TA] = 5.2分钟）和超快Wave-MP3序列（对于32通道线圈，R= 9，TA = 1.15分钟;对于20通道线圈，R= 6，TA = 1.75分钟）。进行区域脑体积的自动分割。两名放射科医师使用半定量视觉评分量表评估局部脑萎缩。研究结果：对于标准和Wave-MPF序列，参与扫描-再扫描实验的健康志愿者的平均绝对对称化百分比变化在任何脑区均无统计学差异。在接受神经退行性疾病评价的患者中，从标准和Wave-MPG获得的体积测量值之间的Dice相似系数范围为0.86至0.95。同样，对于所有区域，脑体积和皮质厚度的绝对对称百分比变化显示，
BACKGROUND AND PURPOSE: Volumetric brain MR imaging typically has long acquisition times. We sought to evaluate an ultrafast MPRAGE sequence based on Wave-CAIPI (Wave-MPRAGE) compared with standard MPRAGE for evaluation of regional brain tissue volumes. MATERIALS AND METHODS: We performed scan-rescan experiments in 10 healthy volunteers to evaluate the intraindividual variability of the brain volumes measured using the standard and Wave-MPRAGE sequences. We then evaluated 43 consecutive patients undergoing brain MR imaging. Patients underwent 3T brain MR imaging, including a standard MPRAGE sequence (acceleration factor [R] = 2, acquisition time [TA] = 5.2 minutes) and an ultrafast Wave-MPRAGE sequence (R= 9, TA = 1.15 minutes for the 32-channel coil;R= 6, TA = 1.75 minutes for the 20-channel coil). Automated segmentation of regional brain volume was performed. Two radiologists evaluated regional brain atrophy using semiquantitative visual rating scales. RESULTS: The mean absolute symmetrized percent change in the healthy volunteers participating in the scan-rescan experiments was not statistically different in any brain region for both the standard and Wave-MPRAGE sequences. In the patients undergoing evaluation for neurodegenerative disease, the Dice coefficient of similarity between volumetric measurements obtained from standard and Wave-MPRAGE ranged from 0.86 to 0.95. Similarly, for all regions, the absolute symmetrized percent change for brain volume and cortical thickness showed