Relation of bronchial responsiveness to body mass index in the ECRHS
Relation of bronchial responsiveness to body mass index in the ECRHS
复制标题
DOI：
10.1136/thorax.57.12.1028
复制
发表时间：
2002-12-01
期刊：
影响因子：
10
通讯作者：
Burney, P
中科院分区：
文献类型：
--
作者：
Chinn, S;Jarvis, D;Burney, P
背景：有大量证据表明哮喘症状与超重或肥胖之间存在关联。然而，一项研究表明，呼吸道反应性(BHR)和体重指数(BMI)之间没有关联，这表明症状与肥胖的关系是由于哮喘诊断的增加。因此，在一项大型多中心研究中，我们调查了BHR与BMI的关系。方法：获得了欧洲共同体呼吸健康调查(ECRHS)第二阶段的11 277名参与者的数据。结果：男性的BHR随着体重指数的增加而增加(体重指数每增加一个单位，BHR斜率变化-0.027，95%可信区间-0.044至-0.010，p=0.002)，但女性的这种关系很弱(-0.014，95%CI-0.033至0.005，p=0.14)。未发现性别与BMI的交互作用(p=0.41)。结论：在ECRHS中BHR与BMI有关。这表明，这种联系并不是因为与正常体重的人相比，肥胖者对症状的诊断或感知更多。这些数据不支持一些研究的发现，即哮喘和肥胖在女性中存在关系，但在男性中没有。
Background: There is substantial evidence for an association between symptoms of asthma and overweight or obesity. However, a study that reported no association between bronchial responsiveness (BHR) and body mass index (BMI) suggested that the relation of symptoms to obesity was due to increased diagnosis of asthma. The relation of BHR to BMI was therefore investigated in a large multi-centre study.Methods: Data were obtained for 11 277 participants in stage II of the European Community Respiratory Health Survey (ECRHS). BHR to methacholine was analysed in relation to BMI adjusted for a number of factors known to be associated with BHR, including baseline lung function and allergen sensitisation, and combined across 34 centres using random effects meta-analysis.Results: BHR increased with increasing BMI in men (ECRHS slope changed by -0.027 for each unit increase in BMI, 95% confidence interval -0.044 to -0.0 10, p=0.002), but the relation in women was weak (-0.0 14, 95% CI -0.033 to 0.005, p=0.14). There was no evidence for an interaction of sex with BMI (p=0.41).Conclusions: BHR is related to BMI in the ECRHS. This suggests that the association is not due to greater diagnosis or perception of symptoms in obese people compared with those of normal weight. The data do not support the finding by some studies of a relation between asthma and obesity in women but not in men.