Pathogenesis gene families in the common minimal genome of Staphylococcus aureus are hypervariable.
Pathogenesis gene families in the common minimal genome of Staphylococcus aureus are hypervariable.
复制标题
金黄色葡萄球菌常见最小基因组中的发病基因家族高度可变。
DOI：
10.1016/j.febslet.2009.03.025
复制
发表时间：
2009
期刊：
影响因子：
3.5
通讯作者：
Cole,AlexanderM
中科院分区：
文献类型：
--
作者：
Sivaraman,Karthikeyan;Cole,AlexanderM
Staphylococcus aureus is a versatile pathogen that shows high levels of inter-strain genetic variability and positive evolution in certain pathogenesis-related genes. Apart from gene content differences, variability in shared genes may affect pathogenicity. Studying such variability requires that the common minimal genome (CMG) be identified. In this study, we have surveyed the CMG of S. aureus with respect to variability amongst orthologous family members, and determined that genes involved in pathogenesis preferentially accumulate variations. A negative correlation between variability of genes and their evolution was found, suggesting a preservation of host-specific function while exhibiting sequence diversity. Variation in key pathogenesis genes in S. aureus might predispose them to functional modulation, thereby playing an important role in evasion of host immunity.
