Comparing global motor characteristics in children and adults with childhood apraxia of speech to a cerebellar stroke patient: evidence for the cerebellar hypothesis in a developmental motor speech disorder
Comparing global motor characteristics in children and adults with childhood apraxia of speech to a cerebellar stroke patient: evidence for the cerebellar hypothesis in a developmental motor speech disorder
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DOI：
10.1080/02699206.2020.1861103
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发表时间：
2020-12-18
影响因子：
1.2
通讯作者：
Rogalsky, Corianne
中科院分区：
文献类型：
--
作者：
Peter, Beate;Bruce, Laurel;Rogalsky, Corianne
儿童期言语失用症（CAS）患者除了言语外，还有其他系统的运动缺陷，以及序列处理的整体缺陷，与小脑功能障碍一致。我们调查了18名儿童和青少年CAS的小脑假说，11名典型的对照组，一名可能有CAS病史的成年人，以及一名有小脑卒中病史的成年人。与对照组相比，CAS儿童和青少年在两种不同音节类型之间交替时快速音节重复的困难最大，在三种不同音节之间切换时困难较小，重复相同音节时没有困难。他们还表现出交替敲击键盘的困难，但不是重复敲击键盘。在音节重复和敲击键盘的任务中，运动速度是相关的，与支配这两个系统的中央运动神经元一致。患有CAS的参与者在精细运动能力测试中得分较低，其中任务需要快速整合复杂的手部运动序列。可能有CAS病史的成人获得的运动表现评分与CAS儿童和青少年的评分基本相似，与持续至成年的运动缺陷一致。有小脑中风病史的参与者在精细和粗大运动能力以及平衡测试中表现出缺陷。他的重复和交替敲击键盘是缓慢的同侧手相对于中风病变。所有CAS参与者和小脑卒中患者的顺序运动功能的共同缺陷与CAS中持续的小脑功能障碍一致。
Individuals with childhood apraxia of speech (CAS) have motor deficits in systems beyond speech and also global deficits in sequential processing, consistent with cerebellar dysfunction. We investigated the cerebellar hypothesis of CAS in 18 children and adolescents with CAS, 11 typical controls, an adult with a probable CAS history, and an adult with a history of a cerebellar stroke. Compared to the controls, children and adolescents with CAS had the greatest difficulty with rapid syllable repetition when alternating between two different syllables types, less difficulty when switching among three different syllables, and no difficulty when repeating the same syllable. They also showed difficulty with alternating but not repetitive key tapping. Motor speeds during the syllable repetition and key tapping tasks where correlated, consistent with a central motor delimiter that governs both systems. Participants with CAS obtained low scores in a test of fine motor ability, where the tasks required rapid integration of complex hand movement sequences. The adult with the probable CAS history obtained motor performance scores that generally resembled those in the children and adolescents with CAS, consistent with motor deficits that persist into adulthood. The participant with the cerebellar stroke history showed deficits in tests of fine and gross motor ability as well as balance. His repetitive and alternating key tapping was slow in the ipsilateral hand relative to the stroke lesion. The shared deficits in sequential motor functions among all participants with CAS and the cerebellar stroke patient are consistent with persisting cerebellar dysfunctions in CAS.