Differences that matter: Major cytotoxic T cell-stimulating minor histocompatibility antigens
Differences that matter: Major cytotoxic T cell-stimulating minor histocompatibility antigens
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DOI：
10.1016/s1074-7613(00)00033-9
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发表时间：
2000-09-01
期刊：
影响因子：
32.4
通讯作者：
Shastri, N
中科院分区：
文献类型：
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作者：
Malarkannan, S;Horng, T;Shastri, N
尽管在MHC匹配的小鼠品系中存在数千种遗传多态性，但一些未知的组织相容性抗原是组织移植物特异性的细胞毒性T细胞靶向的。我们分离到了一个新的BALB的cDNA。确定3号染色体上多态性H28位点的B抗原基因，并产生自然加工的ILENFPRL （IFL8）肽，由Kb MHC呈递给C57BI/6 CTL。针对IFL8/K-b和我们之前鉴定的H60/K-b复合物的特异性CTL代表了B6抗balb的主要部分。B免疫反应。这些抗原的免疫优势可以通过它们在供体与宿主菌株中的差异转录和它们在专业供体抗原呈递细胞中的表达来解释。
Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic H28 locus on chromosome 3 and yields the naturally processed ILENFPRL (IFL8) peptide for presentation by Kb MHC to C57BI/6 CTL. The CTL specific for the IFL8/K-b and our previously identified H60/K-b complexes represent a major fraction of the B6 anti-BALB.B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells.