ACUTE HEPATITIS-B VIRUS-INFECTION - RELATION OF AGE TO THE CLINICAL EXPRESSION OF DISEASE AND SUBSEQUENT DEVELOPMENT OF THE CARRIER STATE
ACUTE HEPATITIS-B VIRUS-INFECTION - RELATION OF AGE TO THE CLINICAL EXPRESSION OF DISEASE AND SUBSEQUENT DEVELOPMENT OF THE CARRIER STATE
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DOI：
10.1093/infdis/151.4.599
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发表时间：
1985-01-01
影响因子：
6.4
通讯作者：
MAYNARD, JE
中科院分区：
文献类型：
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作者：
MCMAHON, BJ;ALWARD, WLM;MAYNARD, JE
阿拉斯加西南部的尤皮克爱斯基摩人是美国任何普通人群中已知的最高的B型肝炎病毒感染流行率。1971年至1976年对1280名血清阴性的尤皮克爱斯基摩人进行了前瞻性血清学调查，发现189名（14.8%）出现了B型肝炎病毒感染的血清学证据。26例（13.8%）在发生血清转换期间发生临床肝炎。具有临床上明显的肝炎的患者的比例随着年龄的增长而增加（P < 0.01），范围从9.5%的感染患者中≤ 0.05岁至1.05岁。4岁至33.3%的感染患者，30岁。188例患者中有25例（13.3%）成为B型肝炎表面抗原的慢性携带者。成为携带者的风险与患者感染时的年龄呈负相关（P = 0.02）。在≤的患者中，4岁时乙肝病毒携带者中慢性B型肝炎的发生率为28.8%，≥ 4岁者为7.7%。30岁。
Yupik Eskimos of southwestern Alaska have the highest known prevalence of hepatitis B virus infection of any general population in the USA. Prospective serological surveys of 1280 seronegative Yupik Eskimos, performed between 1971 and 1976, identified 189 (14.8%) who developed serological evidence of hepatitis B virus infection. Twenty-six (13.8%) developed clinical hepatitis during the interval when seroconversion occurred. The proportion of patients with clinically apparent hepatitis increased with age (P < 0.01), ranging from 9.5% of infections in patients who were .ltoreq. 4 yr old to 33.3% of infections in patients who were .gtoreq. 30 yr old. Twenty-five (13.3%) of the 188 individuals who were studied became chronic carriers of hepatitis B surface antigen. The risk of becoming a carrier was inversely related to the age of the patient at the time of infection (P = 0.02). Among patients who were .ltoreq. 4 yr old when infected, 28.8% became chronic carriers of hepatitis B, as compared with 7.7% of those who were .gtoreq. 30 yr old.