Spatial function in adolescents and young adults with congenital adrenal hyperplasia: Clinical phenotype and implications for the androgen hypothesis
Spatial function in adolescents and young adults with congenital adrenal hyperplasia: Clinical phenotype and implications for the androgen hypothesis
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DOI：
10.1016/j.psyneuen.2015.01.022
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发表时间：
2015-04-01
影响因子：
3.7
通讯作者：
Rovet, Joanne F.
中科院分区：
文献类型：
--
作者：
Hampson, Elizabeth;Rovet, Joanne F.
由于21-羟化酶缺乏而患有先天性肾上腺增生症（CAH）的女性在心理旋转或其他视觉空间能力的测试中表现优于未受影响的女性对照组，但研究结果相互矛盾。我们研究了31名患有CAH的青少年和年轻人以及19名未受影响的兄弟姐妹作为对照，对他们进行了标准化的空间测试和其他性别差异的认知功能测试（语言流畅性、感知速度）。评估了CAH亚型（盐浪费或单纯男性化）的可能作用。只有患有更严重的盐消耗型CAH的雌性，而没有患有简单男性化型CAH的雌性，在心理旋转的测量中表现明显优于性别匹配的兄弟姐妹。在语言流畅性和知觉速度方面，亚型差异不显著。产前生殖器阳刚化的严重程度，而不是产后服药时的年龄，预测了心理旋转测试的准确性。结果与雄激素在中枢神经系统中影响空间能力发展的组织效应的可能性一致。讨论了假设的关键时期时间的含义。(C) 2015 Elsevier Ltd.版权所有。
Females with the classic form of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency are said to perform better than unaffected female controls on tests of mental rotation or other visuospatial abilities, but findings are conflicting. We studied 31 adolescents and young adults with CAH and 19 unaffected sibling controls, who were given standardized spatial tests and tests of other sexually differentiated cognitive functions (verbal fluency, perceptual speed). The possible role of CAH subtype (salt-wasting or simple-virilizing) was evaluated. Only females with the more severe, salt-wasting form of CAH, but not females with the simple-virilizing form, performed significantly better than sex-matched sibling controls on measures of mental rotation. Subtype differences were not significant for verbal fluency or perceptual speed. Severity of prenatal genital virilization, but not postnatal age when medication was started, predicted accuracy on the Mental Rotations Test. Results are consistent with the possibility of an organizational effect of androgens in the central nervous system that impacts the development of spatial abilities. Implications for the timing of the hypothetical critical period are discussed. (C) 2015 Elsevier Ltd. All rights reserved.