Repeatability and reproducibility of fast macular thickness mapping with stratus optical coherence tomography
Repeatability and reproducibility of fast macular thickness mapping with stratus optical coherence tomography
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DOI：
10.1001/archopht.123.10.1330
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发表时间：
2005-10-01
影响因子：
--
通讯作者：
Bandello, F
中科院分区：
文献类型：
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作者：
Polito, A;Del Borrello, M;Bandello, F
目的：确定使用 Stratus 光学相干断层扫描的快速黄斑厚度测绘方案进行视网膜厚度测量的重复性和再现性。方法：由 2 名经验丰富的检查者在同一次就诊期间，对 10 名健康受试者的 10 只眼睛和 15 名患有临床显着黄斑水肿 (CSME) 的糖尿病患者的 15 只眼睛进行瞳孔扩张前后的 2 次扫描。健康受试者在第二次就诊期间还接受了第三次扫描。通过重复性和再现性系数以及组内相关系数计算中心凹中心和 9 个糖尿病视网膜病变早期治疗研究 (ETDRS) 样区域中每个区域的重复性和再现性。结果：健康受试者的重复性系数小于 8%，糖尿病和 CSME 患者的重复性系数小于 9%。患有 CSME 的健康受试者和糖尿病患者的重现性系数分别小于 10% 和 11%。不同观察者或不同访问期间获得的扫描之间没有显着差异。健康受试者和患有 CSME 的糖尿病患者的组内相关系数始终分别大于 0.80 和 0.98。健康受试者和患有 CSME 的糖尿病患者的中央 ETDRS 样区域的平均 +/- SD 厚度分别为 223 14 和 404 108 pm。结论：通过 Stratus 眼相干断层扫描的快速黄斑厚度测绘方案，我们的结果表明，健康受试者和患有 CSME 的糖尿病患者散瞳和未散瞳的视网膜厚度测量是可重复和可重复的。
Objective: To determine the repeatability and reproducibility of retinal thickness measurements with the fast macular thickness mapping protocol of Stratus optical coherence tomography.Methods: Ten eyes of 10 healthy subjects and 15 eyes of 15 diabetic patients with clinically significant macular edema (CSME) underwent 2 scanning sessions before and after pupil dilation during the same visit by 2 experienced examiners. Healthy subjects also received a third scanning session during a second visit. Repeatability and reproducibility for the foveolar center and for each of 9 Early Treatment of Diabetic Retinopathy Study (ETDRS)-like regions were calculated by their repeatability and reproducibility coefficients and intraclass correlation coefficients.Results: The coefficients of repeatability were less than 8% in healthy subjects and less than 9% in patients with diabetes and CSME. The reproducibility coefficients were less than 10% and 11% in healthy subjects and diabetic patients with CSME, respectively. There was no significant difference between scans acquired by different observers or during different visits. The intraclass correlation coefficients were always greater than 0.80 and 0.98 in healthy subjects and diabetic patients with CSME, respectively. Average +/- SD thickness was found to be 223 14 and 404 108 pm for the central ETDRS-like region in healthy subjects and diabetic patients with CSME, respectively.Conclusion: With the fast macular thickness mapping protocol of Stratus ocular coherance tomography, our results indicate that retinal thickness measurements in dilated and undilated eyes of healthy subjects and diabetic patients with CSME are repeatable and reproducible.