Application of Silver-Inorganic Antimicrobial Reagent for Dental Materials. Antimicrobial Action for Streptococcus mutans.
Application of Silver-Inorganic Antimicrobial Reagent for Dental Materials. Antimicrobial Action for Streptococcus mutans.
复制标题
银无机抗菌试剂在牙科材料中的应用。
DOI：
10.2186/jjps.44.651
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
J. Mega
中科院分区：
文献类型：
--
作者：
Takaaki Tanaka;K. Mizukawa;K. Shida;Taira Kobayashi;J. Mega
近来，卫生概念得到了推广，并且已经生产了许多含有抗菌剂的卫生用品。这类试剂分为有机试剂和无机试剂。一些文献指出，这些试剂有许多缺点，如抗菌效果的短时间持久性，加热操作的退化，和物理刺激。此外，有机抗菌剂具有较强的抗菌作用，但长期使用会引起微生物替代和致畸作用，本研究旨在将无机抗菌剂投入实际应用，并考察了银-无机抗菌剂（IONPURETM和NOVARONAG 300 TM）对口腔微生物的影响.抗菌剂（IONPURE和NOVARON）对变形链球菌的最低抑菌浓度（MIC）分别为7.5 mg/m2/和1.3 mg/m2/。抗菌作用为抑菌作用。两种抗菌剂均能显著降低树脂平板上的微生物数量.在含有抗微生物试剂的树脂板上，变形链球菌的MIC为5wt%（IONPURE）和10wt%（NOVARON）。不溶性葡聚糖的合成在含NOVARON的树脂板上受到抑制。另一方面，IONPURE并不那么容易。4.结果表明，IONPURE和NOVARON对变形链球菌有较好的抗菌效果，可用于抗菌假体的制作。
Recently, the concept of hygiene has been promoted, and many sanitary goods that contain antimicrobial reagents have been produced. Such reagents are divided into organic and inorganic ones. Some literature has pointed out that these reagents have many disadvantages, such as short-time durability of antibacterial effect, degeneration by heating operation, and physical irritation. Furthermore, the organic antimicrobial reagents have intensive antimicrobial action, but long use of these reagents may cause microbial substitution and teratogenicity.We aimed to put inorganic antimicrobial reagent into practical use, and the effects of silver-inorganic antimicrobial reagents (IONPURETM and NOVARON AG 300TM) on oral microorganisms were examined.1. Minimum inhibitory concentrations (MICs) of antimicrobial reagents (IONPURE and NOVARON) for Streptococcus mutans were 7.5 mg/m/ and 1.3 mg/m/. The antimicrobial action was bacteriostatic. The microorganisms on resin plates that contained both antimicrobial reagents were remarkably reduced.2. MICs for Streptococcus mutans on resin plates that contained antimicrobial reagents were 5 wt%(IONPURE) and 10 wt%(NOVARON).3. Insoluble glucan synthesis was inhibited on NOVARON-containing resin plates. On the other hand, IONPURE was not so noticeable.4. The surviving microorganisms of Streptococcus mutans on resin plates that contained both antimicrobial reagents (3 wt%) were remarkably decreased.These results suggest that IONPURE and NOVARON were effectual antimicrobial reagents against Streptococcus mutans, and that they were useful for antimicrobial prosthesis.