Cognitive insight in first-episode schizophrenia: Further evidence for a role of the ventrolateral prefrontal cortex
Cognitive insight in first-episode schizophrenia: Further evidence for a role of the ventrolateral prefrontal cortex
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DOI：
10.1016/j.schres.2015.05.009
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发表时间：
2015-08-01
影响因子：
4.5
通讯作者：
Lepage, Martin
中科院分区：
文献类型：
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作者：
Buchy, Lisa;Hawco, Colin;Lepage, Martin
在精神病患者中，自我反思可能依赖于右腹外侧前额叶皮层（VLPFC）。我们使用功能性磁共振成像（fMRI）和一种新颖的虚拟现实范式来评估25名首发精神分裂症（FES）参与者和24名对照者的VLPFC在自我反思中的作用。参与者首先观看了20个字符，每个字符与一个独特的物体/位置配对，然后在fMRI扫描期间完成源记忆判断。用Beck认知洞察力量表测量的自我反思与FES中双侧VLPFC的激活显著正相关，但在对照组中没有，这进一步证明了FES中VLPFC支持自我反思。(C) 2015 Elsevier B.V.版权所有
In people with psychoses, Self-Reflectiveness may rely on the right ventrolateral prefrontal cortex (VLPFC). We used functional magnetic resonance imaging (fMRI) and a novel virtual reality paradigm to evaluate the role of the VLPFC for Self-Reflectiveness in 25 first-episode of schizophrenia (FES) participants and 24 controls. Participants first viewed 20 characters each paired with a unique object/location, and later completed source memory judgements during fMRI scanning. Self-Reflectiveness, measured with the Beck Cognitive Insight Scale, was significantly and positively correlated to activation in bilateral VLPFC in FES, but not in controls, providing further evidence that the VLPFC supports Self-Reflectiveness in FES. (C) 2015 Elsevier B.V. All rights reserved.