Appropriate Dose for Degradation of Levofloxacin Lactate: Gamma Radiolysis and Assessment of Degradation Product Activity and Cytotoxicity
Appropriate Dose for Degradation of Levofloxacin Lactate: Gamma Radiolysis and Assessment of Degradation Product Activity and Cytotoxicity
复制标题
乳酸左氧氟沙星降解的适当剂量：γ射线分解以及降解产物活性和细胞毒性的评估
DOI：
10.1089/ees.2010.0119
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发表时间：
2011-03
影响因子：
1.8
通讯作者：
Zhang Haiqian
中科院分区：
文献类型：
--
作者：
Cao Dongmei;Zhang Xiaohong;Zhao Suying;Guan Yu;Zhang Haiqian
摘要抗生素残留有促进水生系统中耐药菌产生的风险。伽马辐照已被证明是一种有效的技术，以消除污染。然而，降解产物也可能促进抗菌素耐药性，特别是当母体结构的活性部分保持不变时。因此，对降解产物进行了详细分析，以评估其潜在的环境影响。以乳酸左氧氟沙星为靶向抗生素，评价了抗生素的γ辐解作用，并对产品的活性和细胞毒性进行了分析。乳酸左氧氟沙星（10 μg mL-1）在1 kGy剂量下去除>99%。随着辐射剂量的增加，G值范围从1.643到0.193。通过液相色谱-质谱法（LC-MS）鉴定了5种主要辐解产物（质荷比[m/z] 346、330、318、302和274）。结果表明，哌嗪基取代基和喹诺酮类药物的降解。
Abstract Antibiotic residues have the risk of promoting the emergence of resistant bacteria in the aquatic system. Gamma irradiation has been proven to be an effective technique to remove the contamination. However, degradation products might also promote antimicrobial resistance, especially when the active part of the parent structure remains unaltered. Therefore, degradation products have been analyzed in detail to evaluate their potential environmental effect. Levofloxacin lactate was employed as the targeted antibiotic to evaluate gamma radiolysis of antibiotics; the activity and cytotoxicity of the products were also analyzed. Levofloxacin lactate (10 μg mL−1) was removed >99% with the dose of 1 kGy. The G-values ranged from 1.643 to 0.193 with increasing radiation dose. Five main radiolysis products (mass/charge ratio [m/z] 346, 330, 318, 302, and 274) were identified by liquid chromatography-mass spectrometry (LC-MS). Results indicated degradation at the piperazinyl substituent and the quinolones m...
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影响因子：
11.4
作者：
Herbert T. Buxton;D. Kolpin
通讯作者：
Herbert T. Buxton;D. Kolpin
影响因子：
8.8
作者：
Seungho Yu;Byung-Guen Lee;Myunjoo Lee;I. Cho;S. Chang
通讯作者：
Seungho Yu;Byung-Guen Lee;Myunjoo Lee;I. Cho;S. Chang
影响因子：
2.4
作者：
Boon, PI;Cattanach, M
通讯作者：
Cattanach, M
影响因子：
12.8
作者：
A. A. Basfar-A.;H. M. Khan;A. A. Al-Shahrani-A.;W. J. Cooper
通讯作者：
A. A. Basfar-A.;H. M. Khan;A. A. Al-Shahrani-A.;W. J. Cooper
影响因子：
2.9
作者：
Butt, S. Bilal;Qureshi, Rashid Nazir
通讯作者：
Qureshi, Rashid Nazir