Cytoprotection of the gastric epithelium
Cytoprotection of the gastric epithelium
复制标题
胃上皮的细胞保护
DOI：
10.1007/bf01658278
复制
发表时间：
1981
影响因子：
2.6
通讯作者：
K. R. Larsen
中科院分区：
文献类型：
--
作者：
F. Moody;C. Zalewsky;K. R. Larsen
人类胃壁受到多种高度专业化的特性的保护，免受其独特的分泌物盐酸的影响。最重要的是它对氢离子的相对不渗透性。胃表面上皮细胞形成从食道到十二指肠的连续外被，在这种屏障功能中发挥着重要作用。当胃腔内存在酸时，有害物质、败血症或休克对屏障的破坏可能会导致严重的糜烂性胃炎。在粘膜血流量低的时期，这个过程会加速。氢离子反向扩散速率与粘膜血流的关系似乎至关重要。 (a) 抑制胃酸分泌，(b) 加强 H+ 扩散屏障，或 (c) 增加粘膜血流量的因素将保护胃免受损伤。 A、E 和 F 系列前列腺素对实验性糜烂性胃炎的保护水平与其对酸分泌和粘膜灌注的作用不成比例。碱性分泌物的分泌或过滤可能是胃粘膜局部暴露于 16,16-二甲基 (PGE2) 后细胞保护的重要组成部分。在这种情况下粘液释放的作用需要进一步阐明。
The lining of the stomach of man is protected from its unique secretion, hydrochloric acid, by a variety of highly specialized characteristics. Foremost is its relative impermeability to hydrogen ions. The gastric surface epithelial cell which forms a continuous integument from the esophagus to the duodenum plays an important role in this barrier function. Disruption of the barrier by injurious agents, sepsis, or shock may lead to severe erosive gastritis when acid is present within the lumen of the stomach. This process is accelerated during periods of low mucosal blood flow. The relationship of the rate of back‐diffusion of hydrogen ions to mucosal blood flow appears critical. Factors which (a) inhibit acid secretion, (b) strengthen the barrier to H+diffusion, or (c) increase mucosal blood flow will protect the stomach from injury. Prostaglandins of the A, E, and F series offer a level of protection in experimental erosive gastritis that is out of proportion to their effect on acid secretion and mucosal perfusion. The secretion or filtration of an alkaline secretion may be an important component of the cytoprotection which follows the topical exposure of gastric mucosa to 16,16‐dimethyl (PGE2). The role of mucus release in this situation requires further elucidation.