Restricted growth of ent- and tonB mutants of Salmonella enterica serovar Typhi is human Mono Mac 6 monocytic cells
Restricted growth of ent- and tonB mutants of Salmonella enterica serovar Typhi is human Mono Mac 6 monocytic cells
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DOI：
10.1111/j.1574-6968.2001.tb10532.x
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发表时间：
2001-03-01
影响因子：
2.1
通讯作者：
Cabello, FC
中科院分区：
文献类型：
--
作者：
Gorbacheva, VY;Faundez, G;Cabello, FC
Monocytes and macrophages are an important host defense in humans infected with Salmonella enterica serovar Typhi. Bacterial ability to survive in these cells is therefore a crucial virulence characteristic of this pathogen. In this study, we demonstrate that growth of a Salmonella enterica serovar Typhi enterochelin synthesis mutant and a tonB mutant in the human monocyte cell line Mono Mac 6 is restricted compared to that of the parental wild-type Ty2 strain. These results suggest that enterochelin- and TonB-mediated iron uptake plays a role in S, enterica serovar Typhi pathogenesis, and also suggest that mutations in iron uptake may attenuate S. enterica serovar Typhi strains for human beings. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
