THE ERG GENE - A HUMAN-GENE RELATED TO THE ETS ONCOGENE
THE ERG GENE - A HUMAN-GENE RELATED TO THE ETS ONCOGENE
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DOI：
10.1073/pnas.84.17.6131
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发表时间：
1987-09-01
影响因子：
11.1
通讯作者：
PAPAS, TS
中科院分区：
文献类型：
--
作者：
REDDY, ESP;RAO, VN;PAPAS, TS
我们已经分离出一个cDNA克隆，它代表了一个与ets癌基因相关的人类基因erg的完整编码序列。对该cDNA（4.6个碱基长）的核苷酸序列分析表明，该基因编码363个残基的蛋白质，其预测的氨基酸序列显示出近似的同源性。40%和70%分别与v-ets癌基因的5“和3”区的两个结构域相对应。在不同的细胞中观察到erg基因的3.2-至3.6-淀粉酶和5-淀粉酶转录物，其大小不同于先前描述的Hu-ets 1和Hu-ets 2基因。这些结果表明erg基因是ets癌基因家族的一员。
We have isolated a cDNA clone representing the complete coding sequence of a human gene named erg, related to the ets oncogene. Nucleotide sequence analysis of this cDNA (4.6 kilobases long) revealed that this gene encodes a 363-residue protein whose predicted amino acid sequence showed a homology of .apprxeq. 40% and .apprxeq. 70% to two domains corresponding to the 5'' and 3'' regions of v-ets oncogene, respectively. A 3.2- to 3.6-kilobase and .apprxeq.5-kilobase transcript of the erg gene, which differ in size from those of the previously described Hu-ets 1 and Hu-ets 2 genes, were observed in different cells. These results suggest that the erg gene is a member of the ets oncogene family.