Enantioselectivity switch in copper-catalyzed conjugate addition reactions under the influence of a chiral N-heterocyclic carbene-silver complex
Enantioselectivity switch in copper-catalyzed conjugate addition reactions under the influence of a chiral N-heterocyclic carbene-silver complex
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DOI：
10.1039/c5ra25926f
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发表时间：
2016-01-01
期刊：
影响因子：
3.9
通讯作者：
Sakaguchi, Satoshi
中科院分区：
文献类型：
--
作者：
Matsumoto, Keitaro;Nakano, Yuki;Sakaguchi, Satoshi
在Cu（I）盐/N-杂环卡宾（NHC）-Ag络合物催化体系下，Et 2 Zn与2-环己烯-1-酮发生不对称1，4-加成反应，得到光学活性的3-乙基环己酮。在相同的催化体系中，通过改变底物的加入顺序，实现了对映选择性的逆转。
The asymmetric 1,4-addition of Et2Zn to 2-cyclohexen-1-one using a Cu(I) salt/N-heterocyclic carbene (NHC)-Ag complex catalytic system afforded optically active 3-ethylcyclohexanone. The reversal of enantioselectivity using the same catalytic system was achieved by changing the order of the addition of substrates.