IMMUNE-RESPONSE OF CATTLE TO BABESIA-BOVIS (SYN B ARGENTINA) - STUDIES ON THE NATURE AND SPECIFICITY OF PROTECTION
IMMUNE-RESPONSE OF CATTLE TO BABESIA-BOVIS (SYN B ARGENTINA) - STUDIES ON THE NATURE AND SPECIFICITY OF PROTECTION
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DOI：
10.1016/0020-7519(79)90078-x
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发表时间：
1979-01-01
影响因子：
4
通讯作者：
WRIGHT, IG
中科院分区：
文献类型：
--
作者：
MAHONEY, DF;KERR, JD;WRIGHT, IG
对B的免疫应答的研究。牛（= B.阿根廷）在B.使用来自免疫动物的血清的被动转移的Taurus牛表明，效应器机制由与寄生的红细胞反应的抗体介导。在从外周血中去除期间，寄生虫在传代接种到其他未感染动物中时未显示活力降低，因此此时未死亡或不可逆损伤。感染红细胞的调理作用可能是该系统保护的基础。有一些证据表明，在寄生虫株内发生了保护性抗原的微小变异，但这对宿主免疫应答的效率几乎没有影响。抗不同毒株的抗体之间无交叉保护作用。这些菌株间抗体特异性的差异与早期观察结果一致，即感染动物中不同菌株之间通常发生交叉免疫。交叉免疫的机制显然依赖于宿主免疫系统被毒株的保护性抗原激发，从而在攻击后不久发生针对异源毒株的二次应答。
Studies of the immune response to B. bovis (= B. argentina) in B. taurus cattle, using the passive transfer of serum from immune animals, indicated that an effector mechanism was mediated by antibodies which reacted with the parasitized erythrocytes. During removal from the peripheral blood, the parasites did not show reduced viability on subinoculation into other non-infected animals, and thus were not dead or irreversibly damaged at this time. Opsonization of infected erythrocytes was probably the basis of protection by the system. There was some evidence that minor variation of the protective antigen(s) occurred within strains of the parasite but this had little effect on the efficiency of the host''s immune response. There was no cross-protection between the antibodies against different strains. These interstrain differences in antibody specificity were reconciled with earlier observations that cross-immunity commonly occurs between different strains in infected animals. The mechanism of cross-immunity apparently relied on priming of the host''s immune system by the protective antigen(s) of the strain so that a secondary response against the heterologous strain occurred soon after challenge.