Cortico-cortical relations of cat somatosensory areas SIV and SV
Cortico-cortical relations of cat somatosensory areas SIV and SV
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DOI：
10.1080/08990220400012505
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发表时间：
2004-09-01
影响因子：
0.9
通讯作者：
Meredith, MA
中科院分区：
文献类型：
--
作者：
Clemo, HR;Meredith, MA
感觉皮层的特征是一个给定的通道的多个表征，这些表征通常是高度相互关联的，并且是按等级排列的。猫的大脑皮层至少有五个主要区域专门用于躯体感觉处理，但除了SI和SII区外，人们对其他更高水平的区域，如SIV和SV的相互联系知之甚少。因此，本研究探讨了躯体感觉区SIV和SV之间的解剖关系。在成年猫，麦芽凝集素-辣根过氧化物酶(WGA-HRP)注入SIV后，在SV内产生双层逆行标记神经元。将生物素标记的葡聚糖胺(BDA)注入SV时，SIV各板层均可见正交性标记轴突终末，但主要分布在颗粒上。在反向方向上，位于SIV颗粒上层和颗粒下层的神经元投射到SV的所有板层，但也以有利于颗粒上层的方式投射。由于局部抑制回路对特定的躯体感觉反应特性至关重要，因此用免疫细胞化学技术比较了SIV和SV中GABA能神经元及其共定位标记钙结合蛋白(CB)、钙维A酸(CR)和小白蛋白(PV)的分布。尽管在不同的GABA能亚型之间观察到了层层排列的根本差异，但每个亚型在SIV和SV中的分布基本上是相同的。总体而言，这些联系、细胞结构和组织上的相似性表明SIV和SV是相互联系的，并分享了许多躯体感觉加工和联系特征。
Sensory cortex is characterized by multiple representations of a given modality which are generally highly interconnected and hierarchically arranged. The cat cerebral cortex contains at least five major areas dedicated to somatosensory processing, yet aside from areas SI and SII, little is known regarding the interconnectivity of the other, higher-level regions, such as SIV and SV. Therefore, this investigation examined the anatomical relationship of somatosensory areas SIV and SV to each other. In adult cats, wheatgerm agglutinin-horseradish peroxidase (WGA-HRP) injected into SIV produced retrogradely labeled neurons in SV in a bilaminar pattern. When biotinylated dextran amine (BDA) was injected into SV, orthogradely labeled axon terminals were found in SIV across all laminae but predominated in supragranular locations. In the reciprocal direction, neurons located in both the supra- and infragranular layers of SIV projected across all laminae of SV, but also in a manner that favored the supragranular layers. Because local inhibitory circuits are critical for specific somatosensory response properties, the distribution of GABA-ergic neurons and their co-locaaed markers calbindin (CB), calretinin (CR) and parvalbumin (PV) was also compared for SIV and SV using immunocytochemical techniques. Although fundamental differences in laminar arrangement were observed between the different GABA-ergic subtypes, the distribution for each subtype was essentially the same in both SIV and SV. Collectively, these connectional, cytoarchitectonic and organizational similarities indicate that SIV and SV are reciprocally connected and share many somatosensory processing and connectional features.