Trait impulsivity in patients with mood disorders
Trait impulsivity in patients with mood disorders
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DOI：
10.1016/j.jad.2006.09.037
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发表时间：
2007-06-01
影响因子：
6.6
通讯作者：
Soares, J. C.
中科院分区：
文献类型：
--
作者：
Peluso, M. A. M.;Hatch, J. P.;Soares, J. C.
背景资料：冲动性是双相情感障碍躁狂行为的关键组成部分，据报道在双相情感障碍患者中作为一种稳定的特征发生，即一种特质。然而，冲动性还没有被广泛研究抑郁症双相患者。我们评估了抑郁和正常情感的双相和单相患者和健康对照组的冲动性。我们假设，双相情感障碍的受试者将有较高水平的特质impulsivitythan comparators.Methods：24抑郁双相，24抑郁单极，12 euthymic双相，和10 euthymic单极患者，以及51名健康受试者进行了评估与Barratt冲动量表（BIS）。协方差分析与年龄和性别作为协变量被用来比较平均组differences.Results：抑郁的双相情感，正常的双相情感，抑郁的单极患者没有什么不同，并表现出更大的冲动比健康对照组的所有BIS量表。只有在运动冲动性方面，情感正常的单相情感障碍患者的得分高于健康对照组。局限性：在双相情感障碍患者中，有更多的药物滥用史，没有对焦虑和人格障碍进行控制，以及样本量小，限制了本研究的范围。结论：这项研究重复了先前在双相情感障碍患者中发现的稳定特质冲动，并扩展了它们，证实了这一特征可以在抑郁症患者、躁狂症患者和情绪正常的患者中得到证实。特质冲动性可能是反复情绪发作的结果，也可能在发作前就存在，无论哪种方式，它都会影响双相情感障碍的临床表现。(c)2006 Elsevier B.V.保留所有权利。
Background: Impulsivity is a key component of the manic behavior of bipolar disorder and is reported to occur in bipolar patients as a stable characteristic, i.e. a trait. Nevertheless, impulsivity has not been widely studied in depressed bipolar patients. We assessed impulsivity in depressed and euthymic bipolar and unipolar patients and healthy controls. We hypothesized that bipolar subjects would have higher levels of trait impulsivity than the comparison groups.Methods: Twenty-four depressed bipolar, 24 depressed unipolar, 12 euthymic bipolar, and 10 euthymic unipolar patients, as well as 51 healthy subjects were evaluated with the Barratt Impulsiveness Scale (BIS). Analysis of covariance with age and sex as covariates was used to compare mean group differences.Results: Depressed bipolar, euthymic bipolar, and depressed unipolar patients did not differ, and showed greater impulsivity than healthy controls on all of the BIS scales. Euthymic unipolar patients scored higher than healthy controls only on motor impulsivity.Limitations: Higher number of past substance abusers in the bipolar groups, and no control for anxiety and personality disorders, as well as small sample sizes, limit the reach of this study.Conclusions: This study replicates prior findings of stable trait impulsivity in bipolar disorder patients, and extends them, confirming that this trait can be demonstrated in depressed patients, as well as manic and euthymic ones. Trait impulsivity may be the result of repeated mood episodes or be present prior to their onset, either way it would influence the clinical presentation of bipolar disorder. (c) 2006 Elsevier B.V. All rights reserved.