RELEASE OF KALLIKREIN FROM GUINEA PIG LUNG DURING ANAPHYLAXIS
RELEASE OF KALLIKREIN FROM GUINEA PIG LUNG DURING ANAPHYLAXIS
复制标题
过敏反应期间豚鼠肺中激肽释放酶的释放
DOI：
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复制
发表时间：
1966
影响因子：
15.3
通讯作者：
Elmer L. Becker
中科院分区：
文献类型：
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作者：
O. Jonasson;Elmer L. Becker
An antigen-antibody reaction occurring in the perfused sensitized guinea pig lung, has been demonstrated to release kallikrein, a proteolytic enzyme related to the formation of kinins. This lung kallikrein is similar to plasma kallikrein in all properties studied, including susceptibility to the same inhibitors, electrophoretic mobility, and heterogeneity in molecular size. The release of kallikrein during anaphylaxis in the guinea pig lung occurs in the presence of ethylenediaminetetraacetate. Perfusion of ellagic acid into nonsensitized lungs will also release kallikrein, presumably through activation of Hageman factor. On the basis of these findings the hypothesis is suggested that the kallikrein in perfused lung activated by the antigen-antibody reaction is, in fact, plasma kallikrein. It is further suggested that activation of such kallikrein by the antigen-antibody reaction proceeds through Hageman factor.
