New B-cell CD molecules
New B-cell CD molecules
复制标题
DOI：
10.1016/j.imlet.2010.09.019
复制
发表时间：
2011-01-30
影响因子：
4.4
通讯作者：
Engel, Pablo
中科院分区：
文献类型：
--
作者：
Matesanz-Isabel, Jessica;Sintes, Jordi;Engel, Pablo
B细胞不仅在体液免疫中起关键作用，而且还参与广泛的免疫应答，包括抗原呈递和T细胞功能调节。从一系列人类白细胞分化抗原（HLDA）研讨会中鉴定出的细胞表面CD分子有助于人类B细胞群的发现和功能表征。此外，调节B细胞发育、活化和效应子功能的许多事件都是由这些细胞表面分子协调的。在第九届HLDA研讨会（HLDA 9）期间，18个新的CD被分配给在B细胞上表达的细胞表面分子：CD210 a（IL10RA）、CD215（IL15RA）、CD270（TNFRSF14），CD307 a（FCRL 1），CD307 b（FCRL 2），CD307 c（FCRL 3），CD307 d（FCRL 4），CD351（FCAMR），CD352（SLAMF6），CD353（SLAMF8），CD354（TREM1），CD355（CRTAM），CD 357（TNFRSF 18）、CD 358（TNFRSF 21）、CD 360（IL 21 RA）、CD 361（EV 12 B）、CD 362（SDC 2）和CD 363（S1 PR 1）。在这里，我们提出了他们的表达模式的白细胞，包括T淋巴细胞，NK细胞，粒细胞，单核细胞，浆细胞和单核细胞来源的树突状细胞，和几个B细胞亚群。这些新的CD分子在不同分化阶段的B细胞上表达;从骨髓前体前B细胞到浆细胞。其中三个，CD 307 a，CD 307 b和CD 307 d，表现出B细胞限制性表达模式，而其余的也存在于其他白细胞上。在本文中，我们还审查了这些新的CD分子的结构特征，表达和功能。针对新型B细胞表面分子的单克隆抗体的可用性不仅对B细胞生物学，而且对新的诊断和治疗工具的开发具有广泛的意义。(C)2010 Elsevier B. V.保留所有权利。
B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has been instrumental to the discovery and functional characterization of human B-cell populations. Moreover, many events regulating B-cell development, activation, and effector functions are orchestrated by these cell-surface molecules. During the Ninth HLDA Workshop (HLDA9) eighteen new CDs were allocated to cell-surface molecules expressed on B cells: CD210a (IL10RA), CD215 (IL15RA), CD270 (TNFRSF14), CD307a (FCRL1), CD307b (FCRL2), CD307c (FCRL3), CD307d (FCRL4), CD351 (FCAMR), CD352 (SLAMF6), CD353 (SLAMF8), CD354 (TREM1), CD355 (CRTAM), CD357 (TNFRSF18), CD358 (TNFRSF21), CD360 (IL21RA), CD361 (EV12B), CD362 (SDC2), and CD363 (S1PR1). Here we present their expression patterns on leukocytes, including T lymphocytes, NK cells, granulocytes, monocytes, plasmacytoid and monocyte-derived dendritic cells, and several B-cell subsets. These new CD molecules are expressed on B cells at various stages of differentiation; from bone marrow precursor pro-B cells to plasma cells. Three of them, CD307a, CD307b and CD307d, exhibit a B-cell restricted expression pattern, whereas the rest are also present on other leukocytes. In this paper we also review the structural characteristics, expression, and function of these new CD molecules. The availability of monoclonal antibodies directed against novel B cell-surface molecules will have broad implications not only for B-cell biology, but also for the development of new diagnostic and therapeutic tools. (C) 2010 Elsevier B.V. All rights reserved.