Gray matter atrophy pattern in elderly with subjective memory impairment
Gray matter atrophy pattern in elderly with subjective memory impairment
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DOI：
10.1016/j.jalz.2013.05.1764
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发表时间：
2014-01-01
影响因子：
14
通讯作者：
Jessen, Frank
中科院分区：
文献类型：
--
作者：
Peter, Jessica;Scheef, Lukas;Jessen, Frank
背景：主观记忆障碍（SMI）的个体报告记忆恶化，但在认知测试中没有损伤。尽管认知表现正常，但与没有重度精神分裂症的个体相比，他们的认知能力下降的风险可能更高。方法：在226名健康对照者和191名疑似阿尔茨海默病（AD）痴呆患者的独立数据集上，我们使用了一种判别函数（支持向量机）来表征24名重度精神障碍患者和53名对照者的基线灰质模式。我们测试了这些灰质模式与重度精神分裂症的存在、基线时的认知表现和随访时的认知衰退之间的联系。结果：重度精神分裂症患者与非重度精神分裂症对照组相比，AD灰质模式表现出更大的相似性。此外，情节记忆衰退与重度精神障碍组的AD灰质模式有关。结论：我们的研究结果表明，AD患者的灰质萎缩模式与重度精神分裂症之间存在联系。此外，多元模式识别方法似乎是一种敏感的方法，可以识别与重度精神分裂症患者未来记忆衰退相对应的细微大脑变化。(C) 2014阿尔茨海默病协会。版权所有。
Background: Individuals with subjective memory impairment (SMI) report worsening of memory without impairment in cognitive tests. Despite normal cognitive performance, they may be at higher risk of cognitive decline compared with individuals without SMI.Methods: We used a discriminative function (a support vector machine) trained on an independent data set of 226 healthy control subjects and 191 patients with probable Alzheimer's disease (AD) dementia to characterize the baseline gray matter patterns of 24 individuals with SMI and 53 control subjects. We tested for associations of these gray matter patterns with SMI presence, cognitive performance at baseline, and cognitive decline at follow-up.Results: Individuals with SMI showed greater similarity to an AD gray matter pattern compared with control subjects without SMI. In addition, episodic memory decline was associated with an AD gray matter pattern in the SMI group.Conclusions: Our results indicate a link between the gray matter atrophy pattern of patients with AD and the presence of SMI. Furthermore, multivariate pattern recognition approaches seem to be a sensitive method for identifying subtle brain changes that correspond to future memory decline in SMI. (C) 2014 The Alzheimer's Association. All rights reserved.