Poroelastic Modeling of Highly Hydrated Collagen Hydrogels: Experimental Results vs. Numerical Simulation With Custom and Commercial Finite Element Solvers.
Poroelastic Modeling of Highly Hydrated Collagen Hydrogels: Experimental Results vs. Numerical Simulation With Custom and Commercial Finite Element Solvers.
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DOI：
10.3389/fbioe.2018.00142
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发表时间：
2018
影响因子：
5.7
通讯作者：
Lacroix D
中科院分区：
文献类型：
--
作者：
Castro APG;Yao J;Battisti T;Lacroix D
本研究提出了两个有限元（FE）求解器的性能之间的比较高度水合胶原蛋白水凝胶的多孔弹性行为的建模。胶原蛋白水凝胶的表征一直是一个普遍的挑战，因为这是组织工程（TE）应用中最常用的天然生物材料之一。V-Biomech®是面向软组织建模的免费定制FE求解器，而Abaqus®是广泛用于生物力学计算建模的通用商业FE软件包。用这两种求解器进行的多孔弹性模拟与Busby等人和Bargran和Barocas进行的两个实验方案进行了比较，也使用了常用的新胡克超弹性模型的不同实现。在不同的测试和水凝胶特性中，求解器输出之间的平均差异低于5%。因此，差异很小，可以忽略不计，并且在实验发现的样本间差异范围内。这项工作表明，软组织（如胶原蛋白水凝胶）的本构建模可以通过V-Biomech或Abaqus标准选项（无用户子程序）实现，这对生物力学和生物材料研究界非常重要。V-Biomech已经显示出其在软组织生物力学特性验证方面的潜力，而Abaqus的多功能性对于TE应用的建模和分析非常有用，其中还需要捕获其他复杂现象。
This study presents a comparison between the performances of two Finite Element (FE) solvers for the modeling of the poroelastic behavior of highly hydrated collagen hydrogels. Characterization of collagen hydrogels has been a widespread challenge since this is one of the most used natural biomaterials for Tissue Engineering (TE) applications. V-Biomech® is a free custom FE solver oriented to soft tissue modeling, while Abaqus® is a general-purpose commercial FE package which is widely used for biomechanics computational modeling. Poroelastic simulations with both solvers were compared to two experimental protocols performed by Busby et al. and Chandran and Barocas, also using different implementations of the frequently used Neo-Hookean hyperelastic model. The average differences between solvers outputs were under 5% throughout the different tests and hydrogel properties. Thus, differences were small enough to be considered negligible and within the variability found experimentally from one sample to another. This work demonstrates that constitutive modeling of soft tissues, such as collagen hydrogels can be achieved with either V-Biomech or Abaqus standard options (without user-subroutine), which is important for the biomechanics and biomaterials research community. V-Biomech has shown its potential for the validation of biomechanical characterization of soft tissues, while Abaqus' versatility is useful for the modeling and analysis of TE applications where other complex phenomena may also need to be captured.