PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.
PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.
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PD-1阻断剂联合唑来膦酸增强乳腺癌小鼠模型的抗肿瘤功效
DOI：
10.1186/s12885-018-4412-8
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发表时间：
2018-06-19
期刊：
影响因子：
3.8
通讯作者：
Tian J
中科院分区：
文献类型：
--
作者：
Li Y;Du Y;Sun T;Xue H;Jin Z;Tian J
PD-1受体的阻断可能为免疫调节方法治疗乳腺癌(BC)的活性提供概念证据。唑来膦酸(ZA)已被证实可抑制肿瘤细胞的血管生成、侵袭和黏附。本研究的目的是探讨抗T细胞检查点PD-1的单抗联合化疗药物ZA在BC小鼠模型中的作用。通过测量生物发光成像(BLI)和肿瘤体积来监测抗PD-1抗体单独或联合ZA的抗肿瘤效果。结果抗PD-1抗体+ZA联合治疗组小鼠的抗肿瘤反应明显好于未治疗对照组和无明显毒性的单一治疗组。结论本研究为抗PD-1抗体联合ZA联合靶向共信号分子增强BC治疗提供了临床前证据。
BackgroundBlockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, invasion, and adhesion of tumor cells. The aim of this study was to investigate the potential of monoclonal antibody against T cell checkpoint PD-1 in combination with chemotherapeutic drug ZA in BC mouse model.MethodsThe 4 T1-fLuc mouse BC model was used in this study. The anti-tumor efficacy of anti-PD-1 antibody alone or in combination with ZA was monitored by measuring bioluminescence imaging (BLI) and tumor volume. At the end of study, the flow cytometry was used to determine the immune cell population in tumors after different treatment.ResultsThe results showed that mice treated with the combination therapy of anti-PD-1 antibody plus ZA exhibited better antitumor response compared to untreated controls or single therapy with no obvious toxicity.ConclusionOur study provides preclinical evidence for the enhanced BC treatment benefit through targeting co-signal molecules by combining anti-PD-1 antibody plus ZA treatment.
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DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
1.6
作者：
Ren HT;Li YM;Wang XJ;Kang HF;Jin TB;Ma XB;Liu XH;Wang M;Liu K;Xu P;Yao QL;Dai ZJ
通讯作者：
Dai ZJ
影响因子：
30.5
作者：
Latchman, Y;Wood, CR;Freeman, GJ
通讯作者：
Freeman, GJ
影响因子：
51.1
作者：
Coleman, Robert;Cameron, David;Marshall, Helen
通讯作者：
Marshall, Helen
唑来膦酸通过 MCP-1 依赖性巨噬细胞募集阻止间充质干细胞的促肿瘤作用
影响因子：
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作者：
Jia XH;Du Y;Mao D;Wang ZL;He ZQ;Qiu JD;Ma XB;Shang WT;Ding D;Tian J
通讯作者：
Tian J