Locus controlling LDL cholesterol response to dietary cholesterol is on baboon homologue of human chromosome 6
Locus controlling LDL cholesterol response to dietary cholesterol is on baboon homologue of human chromosome 6
复制标题
DOI：
10.1161/01.atv.0000032133.12377.4d
复制
发表时间：
2002-10-01
影响因子：
8.7
通讯作者：
VandeBerg, JL
中科院分区：
文献类型：
--
作者：
Kammerer, CM;Rainwater, DL;VandeBerg, JL
目的-已知对饮食脂质的胆脂血症反应是可遗传的，但可能影响这种反应的基因尚未确定。利用分离分析，我们以前在狒狒中检测到一个潜在的数量性状基因座(QTL)，该基因影响低密度脂蛋白胆固醇对饮食胆固醇的反应。方法和结果--利用方差成分和参数连锁分析方法(2点LOD得分分别为0.008和2.81[基因组概率值为0.008]和2.81[基因组P=0])，我们获得了该潜在的QTL与人类6号染色体上相同的基因座(D6S31 1)连锁的证据。10]、。)。对血清载脂蛋白B饮食反应水平的连锁分析，一个相关的性状，也给出了与这个染色体区域连锁的微弱证据(最高2点Lod得分1.91)。虽然LPA基因座就在附近，但我们没有发现LPA与LPA连锁的证据。结论-本报告首次在灵长类物种中定位了一个潜在的QTL，该QTL影响低密度脂蛋白胆固醇对饮食胆固醇的反应。
Objective-Cholesterolemic responses to dietary lipids are known to, be heritable, but the genes that may affect this response have yet to be identified. Using segregation analysis, we previously detected a potential quantitative trait locus (QTL) in baboons that influenced low density lipoprotein cholesterol response to dietary cholesterol. We performed linkage analyses to locate this QTL by using data on the baboon genetic linkage map.Methods and Results-We obtained evidence for linkage of this potential QTL to the same locus (D6S31 1) on the baboon homologue of human chromosome 6 by using variance components and parametric linkage analysis methods (2-point lod scores 4.17 [genomic probability value 0.008] and 2.81 [genomic P = 0. 10],. respectively). Linkage analyses of serum levels of apolipoprotein B dietary response, a correlated trait, also gave weak suggestive evidence of linkage to this chromosomal region (maximum 2-point lod score 1.91). Although the LPA locus is nearby, we found no evidence of linkage with LPA.Conclusions-This report is the first to localize, in any primate species, a potential QTL that influences low density lipoprotein cholesterol response to dietary cholesterol.