Cytokines and osteolysis around total hip prostheses
Cytokines and osteolysis around total hip prostheses
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DOI：
10.1006/cyto.2000.0753
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发表时间：
2000-10-01
期刊：
影响因子：
3.8
通讯作者：
Toni, A
中科院分区：
文献类型：
--
作者：
Stea, S;Visentin, M;Toni, A
这项工作的目的是评估假体周围的骨质溶解和松动的假体和骨之间的界面处的组织中有利于炎症的细胞因子的存在之间的相关性。在本研究中，对29例接受翻修手术的患者进行了检查。在股骨柄和骨槽水平的骨和植入物之间的界面处采集活检样本。采用免疫组化半定量检测白细胞介素1 α、白细胞介素1 β、白细胞介素6和肿瘤坏死因子，这些细胞因子直接引起骨吸收并间接诱导其他骨吸收细胞因子的合成，通过光学显微镜鉴定并定量磨损颗粒，通过Engh和Bobyn评分对骨溶解的放射学证据进行评分。在界面处收集的组织中，相对于在具有稳定组分的界面处收集的组织，IL 1、IL 6和特别是TNF阳性细胞的百分比增加。在新胶囊中出现的细胞不分泌细胞因子的数量可能与磨损的严重程度有关。骨水泥型假体显示出更高的严重骨质溶解发生率和更高水平的细胞因子。可以得出结论，TNF以及较小程度的IL 1和IL 6与假体周围骨质溶解的严重程度呈正相关，因此可以假设使用抗炎或抗细胞因子药物进行药理学治疗，以限制或避免假体松动。(C)北京大学出版社.
The aim of this work is to assess the correlation between the osteolysis around the prosthesis and the presence of cytokines favouring inflammation in the tissues at the interface between loosened prosthesis and bone. In this study, twenty-nine patients that underwent revision surgery were examined. Bioptic samples were collected at the interface between bone and implant both at the stem and socket level. Semiquantitative immunohistochemistry was performed to detect interleukin 1 alpha, interleukin 1 beta, interleukin 6 and tumour necrosis factor, cytokines that directly cause bone resorption and indirectly induce synthesis of other bone resorbing cytokines, Wear particles were identified and quantified by light microscopy, Radiographic evidence for osteolysis was scored by the Engh and Bobyn score. In tissues collected at the interface, the percentage of cells positive to IL1, IL6 and particularly to TNF increased in relation to the tissues collected at the interface with stable components. The cells occurring in the new capsule do not secrete cytokines in quantities that can be related to severity of wear. Cemented prostheses showed higher incidence of severe osteolysis, and higher levels of cytokines, It can be concluded that TNF, and to a lesser extent IL1 and IL6, are positively related to the severity of osteolysis around the prosthesis and therefore a pharmacological treatment can be hypothesized with anti-inflammatory or anti-cytokine drugs in order to limit or to avoid prosthesis loosening. (C) 2000 Academic Press.