Daytime napping and risk of type 2 diabetes: a meta-analysis of prospective studies
Daytime napping and risk of type 2 diabetes: a meta-analysis of prospective studies
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DOI：
10.1007/s11325-017-1528-z
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发表时间：
2018-09-01
影响因子：
2.5
通讯作者：
Qin, Li-Qiang
中科院分区：
文献类型：
--
作者：
Chen, Guo-Chong;Liu, Meng-Meng;Qin, Li-Qiang
目的前瞻性研究报道了关于日间小睡与2型糖尿病（T2 D）风险之间关系的不一致结果。分类和剂量反应荟萃分析进行量化这种relations.MethodsPotentially合格的研究，通过检索PubMed和Embase数据库。剂量反应效应进行了评估广义最小二乘趋势估计和研究特定的总结相对风险（RRs）与95%的置信区间（CI）计算与random-effects model.ResultsSeven前瞻性研究，包括一个美国，四个欧洲，两个中国队列，涉及249,077名参与者和13,237例T2 D。总体分析显示，习惯性午睡者与非午睡者相比，T2 D风险增加17%（RR=1.17，95%CI 1.08-1.27）。按地区划分，美国、欧洲和中国研究的汇总RR分别为1.21（95% CI 1.17-1.26）、1.15（95% CI 1.03-1.30）和1.23（95% CI 0.87-1.73）。排除已知患有重大慢性疾病的受试者的5项研究得出的汇总RR为1.16（95% CI 1.03-1.30）。一项剂量反应分析表明，白天小睡30分钟/天，每增加一次，T2 D风险增加11%（95%CI 7-16%），尽管没有非线性证据（P-非线性=0.65），但小睡时间短（
PurposeProspective studies reported inconsistent findings on the relationship between daytime napping and risk of type 2 diabetes (T2D). Categorized and dose-response meta-analyses were performed to quantify this relation.MethodsPotentially eligible studies were identified by searching PubMed and Embase databases. Dose-response effects were assessed by the generalized least squares trend estimation and study-specific summary relative risks (RRs) with 95% confidence intervals (CIs) were computed with a random-effects model.ResultsSeven prospective studies including one US, four European, and two Chinese cohorts involving 249,077 participants and 13,237 cases of T2D were included. The overall analyses showed a 17% increased risk of T2D when comparing habitual nappers with non-nappers (RR=1.17, 95% CI 1.08-1.27). By region, the summary RR was 1.21 (95% CI 1.17-1.26), 1.15 (95% CI 1.03-1.30) and 1.23 (95% CI 0.87-1.73) for the US, European, and Chinese studies, respectively. Limiting to five studies that excluded subjects with known major chronic disorders yielded a summary RR of 1.16 (95% CI 1.03-1.30). A dose-response analysis suggested an 11% (95% CI 7-16%) increased T2D risk for each increment in daytime napping of 30min/day and, despite no evidence for nonlinearity (P-nonlinearity=0.65), the increased risk of T2D for short nap (