Influenza Susceptibility, Severity, and Shedding in HIV-Infected Adults: A Review of the Literature
Influenza Susceptibility, Severity, and Shedding in HIV-Infected Adults: A Review of the Literature
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DOI：
10.1093/cid/ciq110
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发表时间：
2011-01-15
影响因子：
11.8
通讯作者：
Brooks, John T.
中科院分区：
文献类型：
--
作者：
Sheth, Anandi N.;Althoff, Keri N.;Brooks, John T.
流感是感染人类免疫缺陷病毒（HIV）的成人呼吸道疾病的常见原因，但目前对HIV感染者的季节性和2009年H1N1大流行性甲型流感（H1N1 pdm）病毒感染的了解有限。在本文中，我们回顾了现有的文献有关流感的易感性，严重程度，并在艾滋病毒感染的成人脱落。数据显示，艾滋病毒感染不会显著增加对流感的易感性。艾滋病与更高的季节性流感相关的发病率和死亡率有关，但在免疫抑制较少的人群中与艾滋病毒感染相关的风险在很大程度上是未知的。免疫受损已被证明会增加流感病毒脱落的幅度和持续时间;然而，这些研究仅限于HIV感染人群。关于H1N1 pdm，数据更加有限。报告对艾滋病毒感染者病情加重表示关切，尽管这可能是由其他合并疾病造成的。需要在HIV感染者中进行前瞻性研究，以更明确地调查流感易感性、严重程度和脱落情况。
Influenza is a common cause of respiratory illness in adults infected with human immunodeficiency virus (HIV), but current knowledge about seasonal and 2009 H1N1 pandemic influenza A (H1N1pdm) virus infections in HIV-infected persons is limited. In this paper, we review the existing literature regarding influenza susceptibility, severity, and shedding in HIV-infected adults. Data show HIV infection does not significantly increase susceptibility to influenza. AIDS is associated with greater seasonal influenza-related morbidity and mortality, but the risk associated with HIV infection among those with less immune suppression is largely unknown. Immunologic compromise has been shown to increase the magnitude and duration of influenza virus shedding; however, these studies are limited within HIV-infected populations. With regards to H1N1pdm, data are even more limited. Reports raise concern of increased severity among HIV-infected persons, although this may be driven by other comorbid illnesses. Prospective studies are needed among HIV-infected persons to more definitively investigate influenza susceptibility, severity, and shedding.