Cellular stress responses: cell survival and cell death.
Cellular stress responses: cell survival and cell death.
复制标题
DOI：
10.1155/2010/214074
复制
发表时间：
2010
影响因子：
--
通讯作者：
Samali A
中科院分区：
文献类型：
--
作者：
Fulda S;Gorman AM;Hori O;Samali A
细胞可以以各种方式对压力作出反应，从激活生存途径到开始细胞死亡，最终消除受损细胞。细胞是否产生保护性或破坏性的应激反应在很大程度上取决于应激的性质和持续时间以及细胞类型。此外，这些反应之间的相互作用往往最终决定了受压细胞的命运。细胞死亡的机制（即凋亡、坏死、焦亡或自噬细胞死亡）取决于各种外源因素以及细胞处理其所暴露的压力的能力。细胞应激反应对人体生理和疾病的影响是多方面的，本文将在糖尿病、帕金森病、心肌梗死和癌症等主要世界健康问题的背景下进行讨论。
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as well as the cell type. Also, there is often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors as well as the cell's ability to handle the stress to which it is exposed. The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer.