Smart capsule for monitoring inflammation profile throughout the gastrointestinal tract.
Smart capsule for monitoring inflammation profile throughout the gastrointestinal tract.
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用于监测整个胃肠道炎症状况的智能胶囊。
DOI：
10.1016/j.biosx.2023.100380
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发表时间：
2023
影响因子：
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通讯作者：
Rahimi,Rahim
中科院分区：
文献类型：
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作者：
Gopalakrishnan,Sarath;Thomas,Rithu;Sedaghat,Sotoudeh;Krishnakumar,Akshay;Khan,Sadid;Meyer,Trevor;Ajieren,Hans;Nejati,Sina;Wang,Jiangshan;Verma,MohitS;Irazoqui,Pedro;Rahimi,Rahim
炎症性肠病（IBD）在过去二十年中已变得惊人地普遍，影响全球680万人，缓解后1年内复发率高达40%。现有的视觉内窥镜检查技术依赖于图像的主观评估，这些图像容易出错并且不足以指示早期IBD，使得它们不适合用于检测IBD患者中的定期复发所需的胃肠道健康的频繁和定量监测。为了解决这些限制，我们实施了一种小型化的智能胶囊（2.2 cm × 11 mm），可以监测活性氧（ROS）水平作为炎症的生物标志物，用于定量和频繁分析整个胃肠道的炎症病变。该胶囊由pH和氧化还原电位（ORP）传感器组成，分别跟踪胶囊的位置和整个胃肠道的ROS水平，以及用于无线传感和数据通信的优化电子接口。所设计的传感器在胃肠道的生理相关范围内（pH：1-8和ORP：−500至+500 mV）提供了线性和稳定的性能。此外，无线接口电子器件的系统设计优化提供了10 ms的有效采样率，可用于长达48 h的长期测量，以全面评估整个胃肠道。作为概念验证，胶囊胶囊在检测炎症风险方面的性能通过对体外细胞培养条件进行测试来验证，模拟健康和发炎的肠道样环境。本文介绍的胶囊在解决对智能可摄取电子产品的新兴需求方面实现了一个新的里程碑，以更好地诊断和治疗消化系统疾病。
Inflammatory bowel disease (IBD) has become alarmingly prevalent in the last two decades affecting 6.8 million people worldwide with a starkly high relapse rate of 40% within 1 year of remission. Existing visual endoscopy techniques rely on subjective assessment of images that are error-prone and insufficient indicators of early-stage IBD, rendering them unsuitable for frequent and quantitative monitoring of gastrointestinal health necessary for detecting regular relapses in IBD patients. To address these limitations, we have implemented a miniaturized smart capsule (2.2 cm × 11 mm) that allows monitoring reactive oxygen species (ROS) levels as a biomarker of inflammation for quantitative and frequent profiling of inflammatory lesions throughout the gastrointestinal tract. The capsule is composed of a pH and oxidation reduction potential (ORP) sensor to track the capsule's location and ROS levels throughout the gastrointestinal tract, respectively, and an optimized electronic interface for wireless sensing and data communication. The designed sensors provided a linear and stable performance within the physiologically relevant range of the GI tract (pH: 1–8 and ORP: −500 to +500 mV). Additionally, systematic design optimization of the wireless interface electronics offered an efficient sampling rate of 10 ms for long-running measurements up to 48 h for a complete evaluation of the entire gastrointestinal tract. As a proof-of-concept, the capsule the capsule's performance in detecting inflammation risks was validated by conducting tests on in vitro cell culture conditions, simulating healthy and inflamed gut-like environments. The capsule presented here achieves a new milestone in addressing the emerging need for smart ingestible electronics for better diagnosis and treatment of digestive diseases.