Normal left ventricular myocardial thickness for middle-aged and older subjects with steady-state free precession cardiac magnetic resonance: the multi-ethnic study of atherosclerosis.
Normal left ventricular myocardial thickness for middle-aged and older subjects with steady-state free precession cardiac magnetic resonance: the multi-ethnic study of atherosclerosis.
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DOI：
10.1161/circimaging.112.973560
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Bluemke DA
中科院分区：
文献类型：
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作者：
Kawel N;Turkbey EB;Carr JJ;Eng J;Gomes AS;Hundley WG;Johnson C;Masri SC;Prince MR;van der Geest RJ;Lima JA;Bluemke DA
左心室心肌厚度（LVMT）增加是几种心脏疾病的特征。本研究的目的是建立心脏MR（CMR）正常LVMT的标准参考值，并评估图像采集平面、人口统计学和LV功能的变化。在动脉粥样硬化多种族研究队列的300名无心脏病的连续参与者（169名女性; 65.6±8.5岁）中，在CMR稳态自由进动电影长轴和短轴图像上测量舒张末期LVMT。中腔水平短轴图像上的平均LVMT女性和男性分别为5.3±0.9mm和6.3±1.1mm。中腔最大LVMT男女平均值分别为7 mm/9mm（长轴）和7 mm/8 mm（短轴）。平均LVMT与体重（0.02 mm/kg，p=0.01）和体表面积（1.1 mm/m2，p<0.001）呈正相关。未发现平均LVMT与年龄或身高之间存在相关性。平均LVMT越大，左室舒张末期容积越小（0.01 mm/ml，p<0.01），左室收缩末期容积越小（-0.01 mm/ml，p=0.01），左室每搏输出量越小（-0.01 mm/ml，p<0.05）。在长轴图像上测量的基底和中腔水平的LVMT略大于（分别为6%和10%）在短轴图像上获得的测量值;长轴图像上的心尖LVMT值比短轴图像上的值小20%。提供了中年和老年受试者的正常壁厚值。女性的正常LVMT低于男性。观察值根据测量的成像平面而变化。
Increased left ventricular myocardial thickness (LVMT) is a feature of several cardiac diseases. The purpose of this study was to establish standard reference values of normal LVMT with cardiac MR (CMR) and to assess variation with image acquisition plane, demographics and LV function. End-diastolic LVMT was measured on CMR steady-state free precession cine long and short axis images in 300 consecutive participants free of cardiac disease (169 women; 65.6±8.5 years) of the Multi-Ethnic Study of Atherosclerosis cohort. Mean LVMT on short axis images at the mid-cavity level was 5.3±0.9mm and 6.3±1.1mm for women and men, respectively. The average of the maximum LVMT at the mid-cavity for women/men were 7mm/9mm (long axis) and 7mm/8mm (short axis). Mean LVMT was positively associated with weight (0.02mm/kg, p=0.01) and body-surface-area (1.1mm/m2, p<0.001). No relationship was found between mean LVMT and age or height. Greater mean LVMT was associated with lower LV end-diastolic volume (0.01mm/ml, p<0.01), a lower LV end-systolic volume (−0.01mm/ml, p=0.01) and lower LV stroke volume (−0.01mm/ml, p<0.05). LVMT measured on long axis images at the basal and mid-cavity level were slightly greater (by 6% and 10%, respectively) than measurements obtained on short axis images; apical LVMT values on long axis images were 20% less than those on short axis images. Normal values for wall thickness are provided for middle-aged and older subjects. Normal LVMT is lower for women than men. Observed values vary depending on the imaging plane for measurement.