Posttranslational Modification of Sodium Channels.
Posttranslational Modification of Sodium Channels.
复制标题
钠通道的翻译后修饰。
DOI：
10.1007/164_2017_69
复制
发表时间：
2018
影响因子：
--
通讯作者：
Cummins,TheodoreR
中科院分区：
文献类型：
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作者：
Pei,Zifan;Pan,Yanling;Cummins,TheodoreR
电压门控钠通道（VGSC）是兴奋性的关键决定因素。VGSC的性质被认为是严格控制的。然而，VGSC也经历了广泛的修饰。已经鉴定了共价修饰神经元和肌肉中的VGSC的多种翻译后修饰。这些包括但不限于磷酸化、泛素化、棕榈酰化、亚硝基化、糖基化和SUMO化。VGSC的翻译后修饰可以对细胞兴奋性产生深远影响，从而促进正常和异常生理学。尽管经过了40年的研究，VGSC调制的复杂性仍有待确定。虽然一些修饰对各种VGSC亚型具有相似的作用，但其他修饰具有亚型特异性相互作用。此外，虽然已经了解了很多关于个体修饰如何影响VGSC功能的信息，但关于不同修饰如何相互作用，还有更多的信息需要了解。在这里，我们回顾了什么是已知的VGSC翻译后修饰的广度和复杂性的监管机制，影响VGSC的属性的重点。
Voltage-gated sodium channels (VGSCs) are critical determinants of excitability. The properties of VGSCs are thought to be tightly controlled. However, VGSCs are also subjected to extensive modifications. Multiple posttranslational modifications that covalently modify VGSCs in neurons and muscle have been identified. These include, but are not limited to, phosphorylation, ubiquitination, palmitoylation, nitrosylation, glycosylation, and SUMOylation. Posttranslational modifications of VGSCs can have profound impact on cellular excitability, contributing to normal and abnormal physiology. Despite four decades of research, the complexity of VGSC modulation is still being determined. While some modifications have similar effects on the various VGSC isoforms, others have isoform-specific interactions. In addition, while much has been learned about how individual modifications can impact VGSC function, there is still more to be learned about how different modifications can interact. Here we review what is known about VGSC posttranslational modifications with a focus on the breadth and complexity of the regulatory mechanisms that impact VGSC properties.