Development and Dosimetry of an `Epithermal' Neutron Beam for Possible Use in Neutron Capture Therapy I. `Epithermal' Neutron Beam Development
Development and Dosimetry of an `Epithermal' Neutron Beam for Possible Use in Neutron Capture Therapy I. `Epithermal' Neutron Beam Development
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可能用于中子捕获治疗的“超热”中子束的开发和剂量测定 I.“超热”中子束开发
DOI：
10.1088/0031-9155/10/4/303
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发表时间：
1965
影响因子：
3.5
通讯作者：
R. Fairchild
中科院分区：
文献类型：
--
作者：
R. Fairchild
通过引入一种合适的中子俘获同位素，比如\(^{10}B\)，然后用一束热中子（能量\(<0.5eV\)）照射该区域，在体内破坏肿瘤细胞的可能性是存在的。利用超热中子（能量\(10KeV\)到\(0.5eV\)）是有优势的，因为它们在组织中的穿透深度比热中子更深。布鲁克海文医学研究反应堆已被用于获取一束超热中子束，该束在组织\(3\)厘米深处产生的热中子通量密度为\(1.42×10^{10}n/cm^{2}\cdot sec\)；所使用的这束中子在单位污染辐射下产生的超热中子数量是最多的。
The possibility exists of destroying neoplastic cells in vivo by introducing a suitable neutron-capturing isotope such as 10B and subsequently irradiating the area with a beam of thermal neutrons (energy < 0·5eV). An advantage can be gained by using epithermal neutrons (energy 10 KeV to 0·5eV), since they provide deeper penetration in tissue than do thermal neutrons. The Brookhaven Medical Research Reactor has been used to obtain an epithermal neutron beam giving a thermal neutron flux density of 1·42×1010 n/cm2-sec at 3 cm depth in tissue; the beam used gave the highest number of epithermal neutrons per unit of contaminating radiations.