Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-γ, and APOE) on human fertility
Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-γ, and APOE) on human fertility
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DOI：
10.1007/s10522-008-9143-9
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发表时间：
2008-10-01
期刊：
影响因子：
4.5
通讯作者：
Scacchi, Renato
中科院分区：
文献类型：
--
作者：
Corbo, Rosa Maria;Ulizzi, Laura;Scacchi, Renato
本研究调查了四个长寿候选基因（ACE，PON 1，PPAR-gamma，APOE）对生育力的可能影响，以确定它们是否在不同的生命年龄具有多效性作用。研究人群为151名健康的无关受试者。只有PPAR-gamma和APOE对生育力有影响。PPAR-gamma Pro/Ala基因型仅在男性中显示出与长寿相关，仅在男性中发现与Pro/Pro基因型（3.3 +/- 1.9; P = 0.001）相比生育更多子女（6.1 +/- 3.3）相关。APOE*2等位基因一直与长寿相关，被证实与最低生育率相关（P = 0.03）。Logistic回归分析表明，APOE和PPAR-gamma基因多态性可能是生殖效率的独立决定因素。这些数据表明，APOE*2等位基因遵循拮抗剂多效性模型，而PPAR-gamma Pro/Ala基因型似乎以性别特异性方式在生命早期和老年发挥有益作用。
The present study investigated for a possible effect on fertility of four longevity candidate genes (ACE, PON1, PPAR-gamma, APOE) in order to determine whether they have a pleiotropic action at different life ages. The study population was 151 healthy unrelated subjects. Only PPAR-gamma and APOE showed an effect on fertility. The PPAR-gamma Pro/Ala genotype, which had showed an association with longevity only in men, was found associated only in men with having produced more children (6.1 +/- 3.3) than the Pro/Pro genotype (3.3 +/- 1.9; P = 0.001). APOE*2 allele, which has been consistently associated with longevity, was confirmed to be associated with the lowest fertility (P = 0.03). The logistic regression analysis indicated that APOE and PPAR-gamma polymorphisms may be considered independent determinants of reproductive efficiency. These data suggest that the APOE*2 allele follows the model of antagonist pleiotropy, while the PPAR-gamma Pro/Ala genotype seems to exert beneficial effects both early in life and in advanced age in a gender-specific way.